UK 1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526518

CAS#: 151271-53-3

Description: UK 1 is a cytotoxic metabolite from Streptomyces sp. 517-02.


Price and Availability

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Price

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UK 1 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526518
Name: UK 1
CAS#: 151271-53-3
Chemical Formula: C22H14N2O5
Exact Mass: 386.0903
Molecular Weight: 386.363
Elemental Analysis: C, 68.39; H, 3.65; N, 7.25; O, 20.70


Synonym: UK 1, UK-1, UK1

IUPAC/Chemical Name: methyl 2'-(2-hydroxyphenyl)-[2,4'-bibenzo[d]oxazole]-4-carboxylate

InChi Key: NGKIDJMAXLRJRL-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14N2O5/c1-27-22(26)14-8-5-11-17-19(14)24-21(29-17)13-7-4-10-16-18(13)23-20(28-16)12-6-2-3-9-15(12)25/h2-11,25H,1H3

SMILES Code: O=C(C1=C2N=C(C3=C4N=C(C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Glover AG, Wiklund H, Rabone M, Amon DJ, Smith CR, O'Hara T, Mah CL, Dahlgren TG. Abyssal fauna of the UK-1 polymetallic nodule exploration claim, Clarion-Clipperton Zone, central Pacific Ocean: Echinodermata. Biodivers Data J. 2016 Jan 25;(4):e7251. doi: 10.3897/BDJ.4.e7251. eCollection 2016. PubMed PMID: 26929713; PubMed Central PMCID: PMC4759440.

2: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Author Index. MAGMA. 2015 Oct;28 Suppl 1:521-36. doi: 10.1007/s10334-015-0491-6. PubMed PMID: 26407576.

3: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Saturday. MAGMA. 2015 Oct;28 Suppl 1:277-418. doi: 10.1007/s10334-015-0489-0. PubMed PMID: 26407574.

4: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Thursday. MAGMA. 2015 Oct;28 Suppl 1:1-135. doi: 10.1007/s10334-015-0487-2. PubMed PMID: 26407572.

5: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: EPOS™ Poster / Paper Poster / Clinical Review Poster / Software Exhibits. MAGMA. 2015 Oct;28 Suppl 1:419-519. doi: 10.1007/s10334-015-0490-7. PubMed PMID: 26407575.

6: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Friday. MAGMA. 2015 Oct;28 Suppl 1:137-276. doi: 10.1007/s10334-015-0488-1. PubMed PMID: 26407573.

7: Shaw L. The Madness of Bedlam: A Time Team Special, Channel 4 [UK], 1 December 2013, 9 pm GMT. Med Hist. 2014 Apr;58(2):311-3. doi: 10.1017/mdh.2014.16. Review. PubMed PMID: 24775439; PubMed Central PMCID: PMC4006151.

8: Ward DN, Talley DC, Tavag M, Menji S, Schaughency P, Baier A, Smith PJ. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12. doi: 10.1016/j.bmcl.2013.12.012. Epub 2013 Dec 9. PubMed PMID: 24360997.

9: Miller CB, Pierlé SA, Brayton KA, Ochoa JN, Shah DH, Lahmers KK. Transcriptional Profiling of a Cross-Protective Salmonella enterica serovar Typhimurium UK-1 dam Mutant Identifies a Set of Genes More Transcriptionally Active Compared to Wild-Type, and Stably Transcribed across Biologically Relevant Microenvironments. Pathogens. 2014;3(2):417-436. PubMed PMID: 25364573; PubMed Central PMCID: PMC4213855.

10: Kanavos P, Angelis A. Acquiring Pharmaceutical Industry Assets in the UK: 1 + 1 = 1? Pharmaceut Med. 2014;28(5):245-248. PubMed PMID: 25346596; PubMed Central PMCID: PMC4203995.

11: Eom JS, Kim JS, Jang JI, Kim HG, Bang IS, Park YK. Effect of iacP mutation on flagellar phase variation in Salmonella enterica serovar typhimurium strain UK-1. J Bacteriol. 2012 Aug;194(16):4332-41. doi: 10.1128/JB.00076-12. Epub 2012 Jun 8. PubMed PMID: 22685287; PubMed Central PMCID: PMC3416257.

12: Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R 3rd. Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One. 2012;7(7):e40645. doi: 10.1371/journal.pone.0040645. Epub 2012 Jul 6. PubMed PMID: 22792393; PubMed Central PMCID: PMC3391293.

13: Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R 3rd. Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). J Bacteriol. 2011 Aug;193(15):4035-6. doi: 10.1128/JB.05224-11. Epub 2011 May 27. PubMed PMID: 21622747; PubMed Central PMCID: PMC3147501.

14: Howarth JL, Lee YB, Uney JB. Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells). Cell Biol Toxicol. 2010 Feb;26(1):1-20. doi: 10.1007/s10565-009-9139-5. Epub 2009 Oct 15. PubMed PMID: 19830583; PubMed Central PMCID: PMC2817806.

15: Kumar D, Jacob MR, Reynolds MB, Kerwin SM. Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1. Bioorg Med Chem. 2002 Dec;10(12):3997-4004. PubMed PMID: 12413851.

16: Burger D. Cell contact interactions in rheumatology, The Kennedy Institute for Rheumatology, London, UK, 1-2 June 2000. Arthritis Res. 2000;2(6):472-6. PubMed PMID: 11219394; PubMed Central PMCID: PMC128876.

17: Ueki M, Shibata K, Taniguchi M. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. IV. Antifungal action of methyl UK-1. J Antibiot (Tokyo). 1998 Sep;51(9):883-5. PubMed PMID: 9820240.

18: Jones DR, Bui TH. Fetal therapy: prospects for transplantation early in pregnancy. In utero stem cell transplantation and gene therapy: second international meeting, Nottingham, UK, 1-2 September 1997. Mol Med Today. 1998 Jan;4(1):10-1. PubMed PMID: 9494961.

19: Shibata K, Kashiwada M, Ueki M, Taniguchi M. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation. J Antibiot (Tokyo). 1993 Jul;46(7):1095-100. PubMed PMID: 8360105.

20: Abstracts of papers presented at the 9th annual meeting of the United Kingdom Environmental Mutagen Society. Portsmouth, Hampshire, UK, 1-3 April 1985. Mutagenesis. 1986 Jan;1(1):67-79. PubMed PMID: 3325737.