ABT-046
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526704

CAS#: 1031336-60-3

Description: ABT-046 is a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. Oral administration of ABT-046 at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels.


Price and Availability

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ABT-046, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526704
Name: ABT-046
CAS#: 1031336-60-3
Chemical Formula: C20H22N4O2
Exact Mass: 350.1743
Molecular Weight: 350.422
Elemental Analysis: C, 68.55; H, 6.33; N, 15.99; O, 9.13


Synonym: ABT-046; ABT 046; ABT046.

IUPAC/Chemical Name: 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid

InChi Key: BWUXSHHOKODNAK-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22N4O2/c21-20-17(12-22-18-9-10-23-24(18)20)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-19(25)26/h5-10,12-14H,1-4,11,21H2,(H,25,26)

SMILES Code: O=C(O)CC1CCC(C2=CC=C(C3=C(N)N4C(N=C3)=CC=N4)C=C2)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

: Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls
HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, Larson KJ,
Lau YY, Marsh KC, Mittelstadt SW, Plata D, Rozema MJ, Segreti JA, Stoner EJ,
Voorbach MJ, Wang X, Xin X, Zhao G, Collins CA, Cox BF, Reilly RM, Kym PR, Souers
AJ. Identification and preliminary characterization of a potent, safe, and orally
efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. J Med Chem.
2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10. PubMed PMID:
22263872.