A-867744
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MedKoo CAT#: 526703

CAS#: 1000279-69-5

Description: A-867744 is a type II PAM with good potency and selectivity. A-867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A-867744 normalized gating deficits.A-867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A-867744 potentiated acetylcholine (ACh)-evoked currents, with an EC(50) value of approximately 1 microM.

Chemical Structure

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A-867744
CAS# 1000279-69-5
Instruction

Theoretical Analysis

MedKoo Cat#: 526703
Name: A-867744
CAS#: 1000279-69-5
Chemical Formula: C20H19ClN2O3S
Exact Mass: 402.08
Molecular Weight: 402.893
Elemental Analysis: C, 59.62; H, 4.75; Cl, 8.80; N, 6.95; O, 11.91; S, 7.96

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
50mg USD 850 2 Weeks
100mg USD 1450 2 Weeks
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Synonym: A-867744; A 867744; A867744;

IUPAC/Chemical Name: 4-(5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl)benzenesulfonamide

InChi Key: ABACVOXFUHDKNZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)

SMILES Code: O=S(C1=CC=C(N2C(C)=C(C(CC)=O)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 402.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pesti K, Lukacs P, Mike A. Type I-like behavior of the type II α7 nicotinic acetylcholine receptor positive allosteric modulator A-867744. PeerJ. 2019 Sep 2;7:e7542. doi: 10.7717/peerj.7542. PMID: 31534841; PMCID: PMC6727837.

2: Newcombe J, Chatzidaki A, Sheppard TD, Topf M, Millar NS. Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model. Mol Pharmacol. 2018 Feb;93(2):128-140. doi: 10.1124/mol.117.110551. Epub 2017 Dec 1. PMID: 29196491; PMCID: PMC5767682.

3: Ween H, Thorin-Hagene K, Andersen E, Grønlien JH, Lee CH, Gopalakrishnan M, Malysz J. Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem Int. 2010 Oct;57(3):269-77. doi: 10.1016/j.neuint.2010.06.005. Epub 2010 Jun 15. PMID: 20558224.

4: Malysz J, Anderson DJ, Grønlien JH, Ji J, Bunnelle WH, Håkerud M, Thorin- Hagene K, Ween H, Helfrich R, Hu M, Gubbins E, Gopalakrishnan S, Puttfarcken PS, Briggs CA, Li J, Meyer MD, Dyhring T, Ahring PK, Nielsen EØ, Peters D, Timmermann DB, Gopalakrishnan M. In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74. doi: 10.1124/jpet.110.167072. Epub 2010 May 26. PMID: 20504915.

5: Hu M, Gopalakrishnan M, Li J. Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br J Pharmacol. 2009 Dec;158(8):1857-64. doi: 10.1111/j.1476-5381.2009.00474.x. PMID: 20050184; PMCID: PMC2807647.

6: Faghih R, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, Ween H, Curtis MP, Sarris KA, Gfesser GA, El-Kouhen R, Robb HM, Radek RJ, Marsh KC, Bunnelle WH, Gopalakrishnan M. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2009 May 28;52(10):3377-84. doi: 10.1021/jm9003818. PMID: 19419141.

7: Malysz J, Grønlien JH, Anderson DJ, Håkerud M, Thorin-Hagene K, Ween H, Wetterstrand C, Briggs CA, Faghih R, Bunnelle WH, Gopalakrishnan M. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. doi: 10.1124/jpet.109.151886. Epub 2009 Apr 23. PMID: 19389923.