A-770041
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406770

CAS#: 869748-10-7

Description: A-770041 is a potent ans selective LCK inhibitor. Concanavalin A-stimulated IL-2 production in whole blood is inhibited by A-770041 with an EC50 of approximately 80 nM. A-770041 is orally bioavailable (F = 34.1 +/- 7.2% at 10 mg/kg) and has a t(1/2) of 4.1 +/- 0.1 h. Concanavalin A-induced IL-2 production in vivo is inhibited by oral administration of A-770041 (in vivo EC50 = 78 +/- 28 nM). A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. A-770041 prevents organ allograft rejection.


Price and Availability

Size
Price

Size
Price

Size
Price

A-770041, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 406770
Name: A-770041
CAS#: 869748-10-7
Chemical Formula: C34H39N9O3
Exact Mass: 621.3176
Molecular Weight: 621.746
Elemental Analysis: C, 65.68; H, 6.32; N, 20.28; O, 7.72


Synonym: A-770041; A 770041; A770041.

IUPAC/Chemical Name: (Z)-N-(4-(1-((1r,4r)-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carbimidic acid

InChi Key: ZMNWFTYYYCSSTF-SOAUALDESA-N

InChi Code: InChI=1S/C34H39N9O3/c1-21(44)41-14-16-42(17-15-41)24-9-11-25(12-10-24)43-33-30(32(35)36-20-37-33)31(39-43)23-8-13-26(29(19-23)46-3)38-34(45)28-18-22-6-4-5-7-27(22)40(28)2/h4-8,13,18-20,24-25H,9-12,14-17H2,1-3H3,(H,38,45)(H2,35,36,37)/t24-,25-

SMILES Code: O/C(C(N1C)=CC2=C1C=CC=C2)=N\C3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y,
Zhang Y, Gray NS, Hornicek FJ. A-770041 reverses paclitaxel and doxorubicin
resistance in osteosarcoma cells. BMC Cancer. 2014 Sep 19;14:681. doi:
10.1186/1471-2407-14-681. PubMed PMID: 25236161; PubMed Central PMCID:
PMC4177239.

2: Meyn MA 3rd, Smithgall TE. Small molecule inhibitors of Lck: the search for
specificity within a kinase family. Mini Rev Med Chem. 2008 Jun;8(6):628-37.
Review. PubMed PMID: 18537718.

3: Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF.
Discovery of A-770041, a src-family selective orally active lck inhibitor that
prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan
1;16(1):118-22. Epub 2005 Oct 10. PubMed PMID: 16216497.

4: Stachlewitz RF, Hart MA, Bettencourt B, Kebede T, Schwartz A, Ratnofsky SE,
Calderwood DJ, Waegell WO, Hirst GC. A-770041, a novel and selective
small-molecule inhibitor of Lck, prevents heart allograft rejection. J Pharmacol
Exp Ther. 2005 Oct;315(1):36-41. Epub 2005 Jul 12. PubMed PMID: 16014572.