A-922500
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526700

CAS#: 959122-11-3

Description: A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that catalyze the final and only committed step in triglyceride biosynthesis.


Price and Availability

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A-922500, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526700
Name: A-922500
CAS#: 959122-11-3
Chemical Formula: C26H24N2O4
Exact Mass: 428.1736
Molecular Weight: 428.488
Elemental Analysis: C, 72.88; H, 5.65; N, 6.54; O, 14.94


Synonym: A-922500; A 922500; A922500.

IUPAC/Chemical Name: (1R,2R)-2-(4'-(3-phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentane-1-carboxylic acid

InChi Key: BOZRFEQDOFSZBV-DHIUTWEWSA-N

InChi Code: InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

SMILES Code: O=C(NC1=CC=CC=C1)NC2=CC=C(C=C2)C3=CC=C(C=C3)C([C@@H]4CCC[C@H]4C(O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tsuda N, Kumadaki S, Higashi C, Ozawa M, Shinozaki M, Kato Y, Hoshida K,
Kikuchi S, Nakano Y, Ogawa Y, Furusako S. Intestine-targeted DGAT1 inhibition
improves obesity and insulin resistance without skin aberrations in mice. PLoS
One. 2014 Nov 18;9(11):e112027. doi: 10.1371/journal.pone.0112027. eCollection
2014. PubMed PMID: 25405858; PubMed Central PMCID: PMC4236014.

2: King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Collins CA,
Voorbach MJ, Zhao G, Mittelstadt SW, Cox BF. In vivo efficacy of acyl CoA:
diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of
postprandial hyperlipidemia. Eur J Pharmacol. 2010 Jul 10;637(1-3):155-61. doi:
10.1016/j.ejphar.2010.03.056. Epub 2010 Apr 10. PubMed PMID: 20385122.

3: King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Zhao G,
Mittelstadt SW, Cox BF. Diacylglycerol acyltransferase 1 inhibition lowers serum
triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. J Pharmacol
Exp Ther. 2009 Aug;330(2):526-31. doi: 10.1124/jpet.109.154047. Epub 2009 May 28.
PubMed PMID: 19478132.