Zolazepam

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526587

CAS#: 31352-82-6

Description: Zolazepam, also known as CI 716, is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It is around four times the potency of diazepam (0.32 mg/kg versus 1.2 mg/kg in animal models) but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.


Price and Availability

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Zolazepam, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526587
Name: Zolazepam
CAS#: 31352-82-6
Chemical Formula: C15H15FN4O
Exact Mass: 286.123
Molecular Weight: 286.3104
Elemental Analysis: C, 62.93; H, 5.28; F, 6.64; N, 19.57; O, 5.59


Synonym: CI 716; CI716; CI-716; Zolazepam; Flupyrazapon

IUPAC/Chemical Name: 4-(2-fluorophenyl)-1,3,8-trimethyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-one

InChi Key: GDSCFOSHSOWNDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15FN4O/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9/h4-7H,8H2,1-3H3

SMILES Code: O=C1CN=C(C2=CC=CC=C2F)C3=C(N(C)N=C3C)N1C


Technical Data

Appearance:
White to off-white crystalline powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yanmaz LE, Dogan E, Okur S, Okumus Z, Ersoz U. Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats. Vet Ophthalmol. 2016 Jun 15. doi: 10.1111/vop.12400. [Epub ahead of print] PubMed PMID: 27302830.

2: Yanmaz LE, Doğan E, Ersöz U, Okumuş Z, Doğan V. Anaesthesia in a Eurasian lynx with an intranasal zolazepam-tiletamine combination. Vet Anaesth Analg. 2016 Jun 16. doi: 10.1111/vaa.12403. [Epub ahead of print] PubMed PMID: 27306966.

3: Jin Y, Qiao Y, Liu X, Pu T, Xu H, Lin D. Immobilization of wild giant panda (Ailuropoda melanoleuca) with dexmedetomidine-tiletamine-zolazepam. Vet Anaesth Analg. 2016 May;43(3):333-7. doi: 10.1111/vaa.12301. Epub 2015 Sep 2. PubMed PMID: 26332691.

4: Arun AS, Krishna S, Antony L, Pillai HC, Venkataramanappa M, Suresh S. Effective Reversible Immobilization of Captive Himalayan Black Bears (Selenarctos thibetanus laniger) with Medetomidine-Tiletamine-Zolazepam and Atipamezole. J Wildl Dis. 2016 Apr 28;52(2):400-2. doi: 10.7589/2014-08-206. PubMed PMID: 27124333.

5: Kim J, Yum H, Jang M, Shin I, Yang W, Baeck S, Suh JH, Lee S, Han SB. A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure. Anal Bioanal Chem. 2016 Jan;408(1):251-63. doi: 10.1007/s00216-015-9099-y. Epub 2015 Oct 10. PubMed PMID: 26454443.

6: Jang M, Park S, Son WG, Jo SM, Hwang H, Seo K, Lee I. Effect of tiletamine-zolazepam on the intraocular pressure of the dog. Vet Ophthalmol. 2015 Nov;18(6):481-4. doi: 10.1111/vop.12237. Epub 2014 Nov 28. PubMed PMID: 25440910.

7: Springer A, Razafimanantsoa L, Fichtel C, Kappeler PM. COMPARISON OF THREE SHORT-TERM IMMOBILIZATION REGIMES IN WILD VERREAUX'S SIFAKAS (PROPITHECUS VERREAUXI): KETAMINE-XYLAZINE, KETAMINE-XYLAZINE-ATROPINE, AND TILETAMINE-ZOLAZEPAM. J Zoo Wildl Med. 2015 Sep;46(3):482-90. doi: 10.1638/2014-0154.1. PubMed PMID: 26352951.

8: De Monte V, Staffieri F, Di Meo A, Vannucci J, Bufalari A. Comparison of ketamine-dexmedetomidine-methadone and tiletamine-zolazepam-methadone combinations for short-term anaesthesia in domestic pigs. Vet J. 2015 Sep;205(3):364-8. doi: 10.1016/j.tvjl.2015.05.011. Epub 2015 May 19. PubMed PMID: 26070949.

9: Spada E, Proverbio D, Bagnagatti De Giorgi G, Perego R, Valena E, Della Pepa A, Baggiani L. Clinical and haematological responses of feline blood donors anaesthetised with a tiletamine and zolazepam combination. J Feline Med Surg. 2015 Apr;17(4):338-41. doi: 10.1177/1098612X14542452. Epub 2014 Jul 11. PubMed PMID: 25015738.

10: Laricchiuta P, De Monte V, Campolo M, Grano F, Crovace A, Staffieri F. Immobilization of captive tigers (Panthera tigris) with a combination of tiletamine, zolazepam, and detomidine. Zoo Biol. 2015 Jan-Feb;34(1):40-5. doi: 10.1002/zoo.21157. Epub 2014 Aug 18. PubMed PMID: 25136814.

11: Mair A, Kloeppel H, Ticehurst K. A comparison of low dose tiletamine-zolazepam or acepromazine combined with methadone for pre-anaesthetic medication in cats. Vet Anaesth Analg. 2014 Nov;41(6):630-5. doi: 10.1111/vaa.12161. Epub 2014 Jul 2. PubMed PMID: 24986565.

12: Lewis JC, Teale P, Webber G, Sear JW, Taylor PM. Comparison of tiletamine and zolazepam pharmacokinetics in tigers (Panthera tigris) and leopards (Panthera pardus): do species differences account for adverse effects in tigers? Vet J. 2014 Sep;201(3):302-6. doi: 10.1016/j.tvjl.2014.05.041. Epub 2014 Jun 11. PubMed PMID: 25011709.

13: Galante R, Muniz JA, Castro PH, Gris VN, Carvalho ER, Amora DS Jr, Vilani RG. Continuous infusion of propofol or intermittent bolus of tiletamine-zolazepam in squirrel monkeys (Saimiri sciureus). Vet Anaesth Analg. 2014 Sep;41(5):506-15. doi: 10.1111/vaa.12155. Epub 2014 Mar 14. PubMed PMID: 24628955.

14: de la Peña JB, Ahsan HM, Dela Peña IJ, Park HB, Kim HJ, Sohn A, Kim YT, Cheong JH. Propofol pretreatment induced place preference and self-administration of the tiletamine-zolazepam combination: implication on drug of abuse substitution. Am J Drug Alcohol Abuse. 2014 Jul;40(4):321-6. doi: 10.3109/00952990.2014.920850. Epub 2014 Jun 20. PubMed PMID: 24950106.

15: Seddighi R, Elliot SB, Whitlock BK, Egger CM, Doherty TJ. Antinociceptive and selected physiological effects of morphine and xylazine on tiletamine-zolazepam anesthesia in llamas. Vet Anaesth Analg. 2014 Jul;41(4):365-71. doi: 10.1111/vaa.12128. Epub 2014 Feb 27. PubMed PMID: 24576096.

16: Sente C, Meisingset EL, Evans AL, Wedul SJ, Zimmermann B, Arnemo JM. Reversible immobilization of free-ranging red deer (Cervus elaphus) with xylazine-tiletamine-zolazepam and atipamezole. J Wildl Dis. 2014 Apr;50(2):359-63. doi: 10.7589/2012-10-267. Epub 2014 Feb 7. PubMed PMID: 24506427.

17: Luengos Vidal EM, Castillo DF, Baglioni J, Manfredi C, Lucherini M, Casanave EB. Chemical immobilisation of free-ranging Pampas foxes (Pseudalopex gymnocercus): Assessment of ketamine-xylazine and tiletamine-zolazepam combinations. Res Vet Sci. 2014 Apr;96(2):371-6. doi: 10.1016/j.rvsc.2013.12.016. Epub 2014 Jan 3. PubMed PMID: 24461336.

18: Kumar A, Mann HJ, Remmel RP, Beilman GJ, Kaila N. Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol). Xenobiotica. 2014 Apr;44(4):379-90. doi: 10.3109/00498254.2013.833362. Epub 2013 Sep 11. PubMed PMID: 24020890.

19: Pinheiro BC, A Silva Dantas Lima D, Lima WC, Quessada AM, Rodrigues MC. Allometric scaling for chemical restraint in greater rheas (Rhea americana) with tiletamine and zolazepam. BMC Vet Res. 2014 Mar 13;10:66. doi: 10.1186/1746-6148-10-66. PubMed PMID: 24625103; PubMed Central PMCID: PMC3995612.

20: Galante R, Muniz JA, Castro PH, Amora DS Jr, Gris VN, Carvalho ER, Vilani RG. Continuous infusion of propofol or intermittent bolus of tiletamine-zolazepam in feline night monkeys (Aotus infulatus). J Med Primatol. 2014 Feb;43(1):22-30. doi: 10.1111/jmp.12089. Epub 2013 Nov 18. PubMed PMID: 24236814.