WAY 150138

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526572

CAS#: 273388-09-3

Description: WAY 150138 can cause the inhibition of the herpes simplex virus.


Price and Availability

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WAY 150138 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526572
Name: WAY 150138
CAS#: 273388-09-3
Chemical Formula: C22H18Cl2FN3O3S
Exact Mass: 493.043
Molecular Weight: 494.3624
Elemental Analysis: C, 53.45; H, 3.67; Cl, 14.34; F, 3.84; N, 8.50; O, 9.71; S, 6.49


Synonym: WAY 150138; WAY150138; WAY-150138

IUPAC/Chemical Name: N-(3-chloro-4-(3-(5-chloro-2,4-dimethoxyphenyl)thioureido)phenyl)-2-fluorobenzamide

InChi Key: NPZHFWHOVNAVCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18Cl2FN3O3S/c1-30-19-11-20(31-2)18(10-15(19)24)28-22(32)27-17-8-7-12(9-14(17)23)26-21(29)13-5-3-4-6-16(13)25/h3-11H,1-2H3,(H,26,29)(H2,27,28,32)

SMILES Code: O=C(NC1=CC=C(NC(NC2=CC(Cl)=C(OC)C=C2OC)=S)C(Cl)=C1)C3=CC=CC=C3F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Newcomb WW, Brown JC. Inhibition of herpes simplex virus replication by WAY-150138: assembly of capsids depleted of the portal and terminase proteins involved in DNA encapsidation. J Virol. 2002 Oct;76(19):10084-8. PubMed PMID: 12208991; PubMed Central PMCID: PMC136520.

2: Newcomb WW, Thomsen DR, Homa FL, Brown JC. Assembly of the herpes simplex virus capsid: identification of soluble scaffold-portal complexes and their role in formation of portal-containing capsids. J Virol. 2003 Sep;77(18):9862-71. PubMed PMID: 12941896; PubMed Central PMCID: PMC224603.

3: Pesola JM, Zhu J, Knipe DM, Coen DM. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol. 2005 Dec;79(23):14516-25. Erratum in: J Virol. 2006 Jun;80(12):6196. PubMed PMID: 16282451; PubMed Central PMCID: PMC1287588.