Way 123398

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526568

CAS#: 138490-53-6

Description: Way 123398 is a class III antiarrhythmic agent.


Price and Availability

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Way 123398 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526568
Name: Way 123398
CAS#: 138490-53-6
Chemical Formula: C19H26ClN5O4S2
Exact Mass: 487.1115
Molecular Weight: 488.018
Elemental Analysis: C, 46.76; H, 5.37; Cl, 7.26; N, 14.35; O, 13.11; S, 13.14


Synonym: Way123398; Way-123398; Way 123398; Way-123,398; Way123,398; Way 123,398

IUPAC/Chemical Name: N-methyl-N-(2-(methyl(1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-4-(methylsulfonamido)benzenesulfonamide hydrochloride

InChi Key: MYKMFRSTVJEDOF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N5O4S2.ClH/c1-22(19-20-17-7-5-6-8-18(17)24(19)3)13-14-23(2)30(27,28)16-11-9-15(10-12-16)21-29(4,25)26;/h5-12,21H,13-14H2,1-4H3;1H

SMILES Code: O=S(C1=CC=C(NS(=O)(C)=O)C=C1)(N(C)CCN(C)C2=NC3=CC=CC=C3N2C)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liang XJ, Taylor B, Cardarelli C, Yin JJ, Annereau JP, Garfield S, Wincovitch S, Szakács G, Gottesman MM, Aszalos A. Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance. Anticancer Res. 2005 Nov-Dec;25(6B):4113-22. PubMed PMID: 16309205.

2: Finlayson K, Turnbull L, January CT, Sharkey J, Kelly JS. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. Eur J Pharmacol. 2001 Oct 26;430(1):147-8. PubMed PMID: 11698075.

3: Higashida H, Brown DA, Robbins J. Both linopirdine- and WAY123,398-sensitive components of I K(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells. Pflugers Arch. 2000 Dec;441(2-3):228-34. PubMed PMID: 11211107.

4: Finlayson K, Pennington AJ, Kelly JS. [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel? Eur J Pharmacol. 2001 Feb 2;412(3):203-12. PubMed PMID: 11166283.

5: Lee JH, Rosen MR. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J Cardiovasc Electrophysiol. 1994 Mar;5(3):232-40. PubMed PMID: 8193739.

6: Spinelli W, Moubarak IF, Parsons RW, Colatsky TJ. Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res. 1993 Sep;27(9):1580-91. PubMed PMID: 8287434.

7: Ellingboe JW, Spinelli W, Winkley MW, Nguyen TT, Parsons RW, Moubarak IF, Kitzen JM, Von Engen D, Bagli JF. Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides. J Med Chem. 1992 Feb 21;35(4):705-16. PubMed PMID: 1542097.

8: Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano-Abad MF, Arcangeli A, Lopez MG, Wanke E. ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J. 2003 Feb;17(2):330-2. Epub 2002 Dec 17. PubMed PMID: 12490549.

9: Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L, Arcangeli A. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia. 2002 Sep;16(9):1791-8. PubMed PMID: 12200695.

10: Cherubini A, Taddei GL, Crociani O, Paglierani M, Buccoliero AM, Fontana L, Noci I, Borri P, Borrani E, Giachi M, Becchetti A, Rosati B, Wanke E, Olivotto M, Arcangeli A. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer. 2000 Dec;83(12):1722-9. PubMed PMID: 11104572; PubMed Central PMCID: PMC2363441.

11: Rosati B, Marchetti P, Crociani O, Lecchi M, Lupi R, Arcangeli A, Olivotto M, Wanke E. Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release. FASEB J. 2000 Dec;14(15):2601-10. PubMed PMID: 11099479.

12: Selyanko AA, Hadley JK, Wood IC, Abogadie FC, Delmas P, Buckley NJ, London B, Brown DA. Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J Neurosci. 1999 Sep 15;19(18):7742-56. PubMed PMID: 10479678.

13: Meves H, Schwarz JR, Wulfsen I. Separation of M-like current and ERG current in NG108-15 cells. Br J Pharmacol. 1999 Jul;127(5):1213-23. PubMed PMID: 10455268; PubMed Central PMCID: PMC1566115.

14: Faravelli L, Arcangeli A, Olivotto M, Wanke E. A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization. J Physiol. 1996 Oct 1;496 ( Pt 1):13-23. Erratum in: J Physiol (Lond) 1997 Aug 1;502(Pt 3):715. PubMed PMID: 8910192; PubMed Central PMCID: PMC1160820.

15: Spinelli W, Parsons RW, Colatsky TJ. Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol. J Cardiovasc Pharmacol. 1992 Dec;20(6):913-22. PubMed PMID: 1282594.

16: Becchetti A, De Fusco M, Crociani O, Cherubini A, Restano-Cassulini R, Lecchi M, Masi A, Arcangeli A, Casari G, Wanke E. The functional properties of the human ether-à-go-go-like (HELK2) K+ channel. Eur J Neurosci. 2002 Aug;16(3):415-28. PubMed PMID: 12193184.