Way 120491

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526565

CAS#: 124916-54-7

Description: Way 120491 activates ATP-sensitive potassium channels.


Price and Availability

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Price

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Way 120491 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526565
Name: Way 120491
CAS#: 124916-54-7
Chemical Formula: C20H18F3NO4
Exact Mass: 393.1188
Molecular Weight: 393.3622
Elemental Analysis: C, 61.07; H, 4.61; F, 14.49; N, 3.56; O, 16.27


Synonym: Way-120,491; Way120491; Way-120491; Way 120491; Celikalim

IUPAC/Chemical Name: 2-(3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)chroman-4-yl)isoindolin-1-one

InChi Key: ZORATYFUTXFLJS-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H18F3NO4/c1-19(2)17(25)16(24-10-11-5-3-4-6-13(11)18(24)26)14-9-12(27-20(21,22)23)7-8-15(14)28-19/h3-9,16-17,25H,10H2,1-2H3

SMILES Code: O=C1N(C2C(O)C(C)(C)OC3=CC=C(OC(F)(F)F)C=C23)CC4=C1C=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: de Lorenzi FG. Celikalim (WAY-120491) increases K+ outward flux in dog and human airway smooth muscle. Pulm Pharmacol. 1994 Apr;7(2):129-35. PubMed PMID: 8081073.

2: Wojdan A, Freeden C, Woods M, Oshiro G, Spinelli W, Colatsky TJ, Sheldon JH, Norton NW, Warga D, Antane MM, Antane SA, Butera JA, Argentieri TM. Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1410-8. PubMed PMID: 10336534.

3: Furspan PB. WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery. Eur J Pharmacol. 1992 Nov 17;223(2-3):201-3. PubMed PMID: 1478268.

4: Evans JM, Smith RJ, Stemp G. Separation of the enantiomers of some potassium channel activators using an alpha 1-acid glycoprotein column. J Chromatogr. 1992 Oct 9;623(1):163-7. PubMed PMID: 1452627.

5: Kitzen JM, McCallum JD, Harvey C, Morin ME, Oshiro GT, Colatsky TJ. Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine. Pharmacology. 1992;45(2):71-82. PubMed PMID: 1523216.

6: Hohman TC, Cotter MA, Cameron NE. ATP-sensitive K(+) channel effects on nerve function, Na(+), K(+) ATPase, and glutathione in diabetic rats. Eur J Pharmacol. 2000 Jun 2;397(2-3):335-41. PubMed PMID: 10844132.

7: Patelunas-Hoffman DM, Carmint WJ, Colatsky TJ, Fenichel RL. Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis. Thromb Res. 1994 Jun 1;74(5):441-52. PubMed PMID: 8085245.

8: Lodge NJ, Colatsky TJ, Cullinan CA, Follmer CH. Electromechanical effects of the putative potassium channel activator celikalim (WAY-120,491) on feline atrial and ventricular muscle. J Pharmacol Exp Ther. 1992 Jun;261(3):1153-9. PubMed PMID: 1602381.

9: Lodge NJ, Cohen RB, Havens CN, Colatsky TJ. The effects of the putative potassium channel activator WAY-120,491 on 86Rb efflux from the rabbit aorta. J Pharmacol Exp Ther. 1991 Feb;256(2):639-44. PubMed PMID: 1899702.