Way 100289

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526563

CAS#: 136013-69-9

Description: Way 100289 is a selective 5-HT3 receptor antagonist.


Price and Availability

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Price

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Way 100289 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526563
Name: Way 100289
CAS#: 136013-69-9
Chemical Formula: C20H27N3O3
Exact Mass: 357.2052
Molecular Weight: 357.454
Elemental Analysis: C, 67.20; H, 7.61; N, 11.76; O, 13.43


Synonym: Way 100289; Way-100289; Way100289

IUPAC/Chemical Name: 2-(cyclopropylmethoxy)-N-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)benzamide

InChi Key: VFRIHPWRNNTKEX-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H27N3O3/c1-23-15-8-9-16(23)11-14(10-15)21-20(25)22-19(24)17-4-2-3-5-18(17)26-12-13-6-7-13/h2-5,13-16H,6-12H2,1H3,(H2,21,22,24,25)

SMILES Code: O=C(NC(NC1CC(N2C)CCC2C1)=O)C3=CC=CC=C3OCC4CC4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Rodgers RJ, Cole JC, Tredwell JM. Profile of action of 5-HT3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice. Psychopharmacology (Berl). 1995 Feb;117(3):306-12. PubMed PMID: 7770606.

2: Hodges H, Sowinski P, Sinden JD, Netto CA, Fletcher A. The selective 5-HT3 receptor antagonist, WAY100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system. Psychopharmacology (Berl). 1995 Feb;117(3):318-32. PubMed PMID: 7770608.

3: Bill DJ, Fletcher A, Glenn BD, Knight M. Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety. Eur J Pharmacol. 1992 Aug 6;218(2-3):327-34. PubMed PMID: 1358637.