Henagliflozin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326677

CAS#: 1623804-44-3

Description: Henagliflozin, also known as SHR3824, is potent, oral and selective SGLT2 inhibitor. Henagliflozin exhibits antidiabetic efficacy in rodent models. SHR3824 potently inhibited human SGLT2 in vitro, but exerted much weak inhibition on human SGLT1 (the IC50 values of SHR3824 against human SGLT2 and SGLT1 were 2.38 and 4324 nmol/L, respectively). Acute oral administration of SHR3824 (0.3, 1.0, 3.0 mg/kg) dose-dependently improved glucose tolerance in ICR mice, and reduced hyperglycemia by increasing urinary glucose excretion in GK rats and db/db mice.

Chemical Structure

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Henagliflozin
CAS# 1623804-44-3
Instruction

Theoretical Analysis

MedKoo Cat#: 326677
Name: Henagliflozin
CAS#: 1623804-44-3
Chemical Formula: C22H24ClFO7
Exact Mass: 454.12
Molecular Weight: 454.875
Elemental Analysis: C, 58.09; H, 5.32; Cl, 7.79; F, 4.18; O, 24.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SHR3824; SHR-3824; SHR 3824; Henagliflozin

IUPAC/Chemical Name: (1R,2S,3S,4R,5R)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

InChi Key: HYTPDMFFHVZBOR-VNXMGFANSA-N

InChi Code: InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22+/m0/s1

SMILES Code: O[C@@H]1[C@@](O2)(CO)CO[C@@]2(C3=CC=C(Cl)C(CC4=CC=C(OCC)C(F)=C4)=C3)[C@H](O)[C@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 454.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yong X, Wen A, Liu X, Liu H, Liu YP, Li N, Hu T, Chen Y, Wang M, Wang L, Dai
X, Huang J, Li J, Shen H. Pharmacokinetics and Pharmacodynamics of Henagliflozin,
a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2
Diabetes Mellitus. Clin Drug Investig. 2016 Mar;36(3):195-202. doi:
10.1007/s40261-015-0366-7. PubMed PMID: 26692004.


2: Wang L, Wu C, Shen L, Liu H, Chen Y, Liu F, Wang Y, Yang J. Evaluation of
drug-drug interaction between henagliflozin, a novel sodium-glucose
co-transporter 2 inhibitor, and metformin in healthy Chinese males. Xenobiotica.
2016 Aug;46(8):703-8. doi: 10.3109/00498254.2015.1113576. Epub 2015 Nov 26.
PubMed PMID: 26608671.


3: Yan PK, Zhang LN, Feng Y, Qu H, Qin L, Zhang LS, Leng Y. SHR3824, a novel
selective inhibitor of renal sodium glucose cotransporter 2, exhibits
antidiabetic efficacy in rodent models. Acta Pharmacol Sin. 2014
May;35(5):613-24. doi: 10.1038/aps.2013.196. PubMed PMID: 24786232; PubMed
Central PMCID: PMC4814034.