NT-157

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406751

CAS#: 1384426-12-3

Description: NT157 is discontinued for commercial reason.

Chemical Structure

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NT-157
CAS# 1384426-12-3
Instruction

Theoretical Analysis

MedKoo Cat#: 406751
Name: NT-157
CAS#: 1384426-12-3
Chemical Formula: C16H14BrNO5S
Exact Mass: 410.98
Molecular Weight: 412.254
Elemental Analysis: C, 46.62; H, 3.42; Br, 19.38; N, 3.40; O, 19.40; S, 7.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NT-157; NT 157; NT157.

IUPAC/Chemical Name: (2E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-2-propenethioamide

InChi Key: NIPUPOUEGOSAAO-OWOJBTEDSA-N

InChi Code: InChI=1S/C16H14BrNO5S/c17-10-3-8(4-11(19)15(10)22)1-2-14(24)18-7-9-5-12(20)16(23)13(21)6-9/h1-6,19-23H,7H2,(H,18,24)/b2-1+

SMILES Code: S=C(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C2=CC(O)=C(O)C(Br)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rampias T, Favicchio R, Stebbing J, Giamas G. Targeting tumor-stroma
crosstalk: the example of the NT157 inhibitor. Oncogene. 2016 May
19;35(20):2562-4. doi: 10.1038/onc.2015.392. Epub 2015 Oct 19. PubMed PMID:
26477311.


2: Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K,
Levitzki A, Karin M. Targeting colorectal cancer via its microenvironment by
inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.
Oncogene. 2016 May 19;35(20):2634-44. doi: 10.1038/onc.2015.326. Epub 2015 Sep
14. PubMed PMID: 26364612; PubMed Central PMCID: PMC4791217.


3: Flashner-Abramson E, Klein S, Mullin G, Shoshan E, Song R, Shir A, Langut Y,
Bar-Eli M, Reuveni H, Levitzki A. Targeting melanoma with NT157 by blocking Stat3
and IGF1R signaling. Oncogene. 2016 May 19;35(20):2675-80. doi:
10.1038/onc.2015.229. Epub 2015 Jun 29. PubMed PMID: 26119932.


4: Garofalo C, Capristo M, Mancarella C, Reunevi H, Picci P, Scotlandi K.
Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma
Cell Lines. Front Endocrinol (Lausanne). 2015 May 13;6:74. doi:
10.3389/fendo.2015.00074. eCollection 2015. PubMed PMID: 26029165; PubMed Central
PMCID: PMC4429561.


5: Ibuki N, Ghaffari M, Reuveni H, Pandey M, Fazli L, Azuma H, Gleave ME,
Levitzki A, Cox ME. The tyrphostin NT157 suppresses insulin receptor substrates
and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014
Dec;13(12):2827-39. doi: 10.1158/1535-7163.MCT-13-0842. Epub 2014 Sep 29. PubMed
PMID: 25267499.