CI 972

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524720

CAS#: 115787-68-3

Description: CI 972 is novel purine nucleoside phosphorylase inhibitor. It is a T cell-selective immunosuppressive agent. CI-972 inhibited proliferation of human MOLT-4 (T cell) but not MGL-8 (B cell) lymphoblasts with respective IC50s of 3.0 and greater than 50 microM when tested with 10 microM 2'-deoxyguanosine.

Chemical Structure

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CI 972
CAS# 115787-68-3
Instruction

Theoretical Analysis

MedKoo Cat#: 524720
Name: CI 972
CAS#: 115787-68-3
Chemical Formula: C11H12ClN5OS
Exact Mass: 0.00
Molecular Weight: 297.760
Elemental Analysis: C, 44.37; H, 4.06; Cl, 11.91; N, 23.52; O, 5.37; S, 10.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CI 972; CI972; CI-972.

IUPAC/Chemical Name: 4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride

InChi Key: JXUVRNVXFVJOCX-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H11N5OS.ClH/c12-9-6(3-5-1-2-18-4-5)7-8(14-9)10(17)16-11(13)15-7;/h1-2,4,14-15H,3,12H2,(H2,13,16,17);1H

SMILES Code: c1([nH]c2c(c(n1)=O)[nH]c(c2Cc1cscc1)N)N.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wilburn DJ, Dong MK, Gilbertsen RB. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR). Agents Actions. 1993;39 Spec No:C96-8. PubMed PMID: 8273599.

2: Gilbertsen RB, Josyula U, Sircar JC, Dong MK, Wu WS, Wilburn DJ, Conroy MC. Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochem Pharmacol. 1992 Sep 1;44(5):996-9. PubMed PMID: 1530667.

3: Gilbertsen RB, Dong MK, Wilburn DJ, Kossarek LM, Sircar JC, Kostlan CR, Conroy MC. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. PubMed PMID: 1789255.

4: Gilbertsen RB, Dong MK, Kossarek LM, Sircar JC, Kostlan CR, Conroy MC. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. PubMed PMID: 1908235.