CI 951

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524718

CAS#: 126661-07-2

Description: CI 951 is a novel dihydronaphthyridine Ca2+ antagonist, channel blocker. CI-951 may be a useful therapeutic agent for focal cerebral ischemia. It has potential as a cerebral vasodilator.

Chemical Structure

img
CI 951
CAS# 126661-07-2
Instruction

Theoretical Analysis

MedKoo Cat#: 524718
Name: CI 951
CAS#: 126661-07-2
Chemical Formula: C22H23F3N2O3
Exact Mass: 420.17
Molecular Weight: 420.420
Elemental Analysis: C, 62.85; H, 5.51; F, 13.56; N, 6.66; O, 11.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CI 951; CI-951; CI951.

IUPAC/Chemical Name: 1,6-Naphthyridine-3-carboxylic acid, 1,4-dihydro-2-methyl-5-(1-methylethoxy)-4-(2-(trifluoromethyl)phenyl)-, ethyl ester

InChi Key: XVXQOAYCEUDQTQ-SFHVURJKSA-N

InChi Code: InChI=1S/C22H23F3N2O3/c1-5-29-21(28)17-13(4)27-16-10-11-26-20(30-12(2)3)19(16)18(17)14-8-6-7-9-15(14)22(23,24)25/h6-12,18,27H,5H2,1-4H3/t18-/m0/s1

SMILES Code: N1C(=C([C@@H](c2c(nccc12)OC(C)C)c1c(cccc1)C(F)(F)F)C(=O)OCC)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Knight WA, Hart KW, Adeoye OM, Bonomo JB, Keegan SP, Ficker DM, Szaflarski JP, Privitera MD, Lindsell CJ. The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest. Epilepsy Res. 2013 Oct;106(3):396-402. doi: 10.1016/j.eplepsyres.2013.06.018. Epub 2013 Jul 29. PubMed PMID: 23906560; PubMed Central PMCID: PMC3961478.

2: Papadakaki M, Tzamalouka GS, Chatzifotiou S, Chliaoutakis J. Seeking for risk factors of Intimate Partner Violence (IPV) in a Greek national sample: the role of self-esteem. J Interpers Violence. 2009 May;24(5):732-50. doi: 10.1177/0886260508317181. Epub 2008 May 7. PubMed PMID: 18463309.

3: Koike K, Takayanagi I, Takiguchi S, Urita Y, Miyake N. Ca-blocking action of stereoisomers of CI-951, (+)-CI-951 (NC-1500) and (-)-CI-951 in the isolated muscle preparations. Gen Pharmacol. 1992 Mar;23(2):207-10. PubMed PMID: 1639233.

4: Pucilowski O, Rezvani AH, Janowsky DS. Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438. Psychopharmacology (Berl). 1992;107(2-3):447-52. PubMed PMID: 1615142.

5: Meyer FB, Anderson RE, Sundt TM Jr. The novel dihydronaphthyridine Ca2+ channel blocker CI-951 improves CBF, brain pHi, and EEG recovery in focal cerebral ischemia. J Cereb Blood Flow Metab. 1990 Jan;10(1):97-103. PubMed PMID: 2298840.