Candoxatrilat

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524548

CAS#: 123122-54-3

Description: Candoxatrilat, also known as U 73967 and UK69578, is an active neutral endopeptidase inhibitor that reduces degradation of atrial natriuretic peptide. Candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action.


Price and Availability

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Candoxatrilat, purity > 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524548
Name: Candoxatrilat
CAS#: 123122-54-3
Chemical Formula: C20H33NO7
Exact Mass: 399.2257
Molecular Weight: 399.48
Elemental Analysis: C, 60.13; H, 8.33; N, 3.51; O, 28.04


Synonym: U 73967; U-73967; U73967; UK69578; UK-69578; UK 69578; Candoxatrilate; Candoxatrilat.

IUPAC/Chemical Name: (1R,4s)-4-(1-((S)-2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentanecarboxamido)cyclohexanecarboxylic acid

InChi Key: ACZWIDANLCXHBM-HRCADAONSA-N

InChi Code: InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-,16+/m0/s1

SMILES Code: COCCOC[C@@H](C(=O)O)CC1(CCCC1)C(=O)N[C@H]2CC[C@H](CC2)C(=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kaye B, Brearley CJ, Cussans NJ, Herron M, Humphrey MJ, Mollatt AR. Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril. Xenobiotica. 1997 Oct;27(10):1091-102. PubMed PMID: 9364744.

2: Barclay PL, Bennett JA, Greengrass PM, Griffin A, Samuels GM, Shepperson NB. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade. Biochem Pharmacol. 1992 Sep 25;44(6):1013-22. PubMed PMID: 1417928.

3: Barclay PL, Bennett JA, Samuels GM, Shepperson NB. The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action. Biochem Pharmacol. 1991 Mar 1;41(5):841-4. PubMed PMID: 1847819.