Carabersat

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MedKoo CAT#: 524550

CAS#: 184653-84-7

Description: Carabersat, also known as SB204269, is an ATP-sensitive potassium channel (K-ATP) opener potentially for the treatment of epilepsy. SB-204269 proved to be an orally-effective anticonvulsant agent. SB-204269 also selectively reduced focal electrographic seizure activity in an in vitro elevated K+ rat hippocampal slice model at concentrations (0.1-10 microM) that had no effect on normal synaptic activity and neuronal excitability.

Chemical Structure

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Carabersat
CAS# 184653-84-7
Instruction

Theoretical Analysis

MedKoo Cat#: 524550
Name: Carabersat
CAS#: 184653-84-7
Chemical Formula: C20H20FNO4
Exact Mass: 357.14
Molecular Weight: 357.380
Elemental Analysis: C, 67.22; H, 5.64; F, 5.32; N, 3.92; O, 17.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Carabersat; Sb 204269-eo; SB-204269; SB 204269; SB204269.

IUPAC/Chemical Name: N-((3R,4S)-6-acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-4-fluorobenzamide

InChi Key: RCLXAPJEFHPYEG-ZWKOTPCHSA-N

InChi Code: InChI=1S/C20H20FNO4/c1-11(23)13-6-9-16-15(10-13)17(18(24)20(2,3)26-16)22-19(25)12-4-7-14(21)8-5-12/h4-10,17-18,24H,1-3H3,(H,22,25)/t17-,18+/m0/s1

SMILES Code: C(c1ccc(cc1)F)(=O)N[C@@H]1[C@H](C(Oc2ccc(cc12)C(=O)C)(C)C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Luszczki JJ. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009 Mar-Apr;61(2):197-216. Review. PubMed PMID: 19443931.

2: Bigal ME, Krymchantowski AV, Rapoport AM. Prophylactic migraine therapy: emerging treatment options. Curr Pain Headache Rep. 2004 Jun;8(3):178-84. Review. PubMed PMID: 15115635.

3: Hovinga CA. Novel anticonvulsant medications in development. Expert Opin Investig Drugs. 2002 Oct;11(10):1387-406. Review. PubMed PMID: 12387702.

4: Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E. Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI). Epilepsy Res. 2002 Sep;51(1-2):31-71. PubMed PMID: 12350382.

5: Nicolson A, Leach JP. Future prospects for the drug treatment of epilepsy. CNS Drugs. 2001;15(12):955-68. Review. PubMed PMID: 11735615.

6: Parsons AA, Bingham S, Raval P, Read S, Thompson M, Upton N. Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes. Br J Pharmacol. 2001 Apr;132(7):1549-57. PubMed PMID: 11264249; PubMed Central PMCID: PMC1572685.