Camobucol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524543

CAS#: 216167-92-9

Description: Camobucol is an antioxidant that inhibits vascular cell adhesion molecule-1 expression used for the treatment of inflammatory diseases.


Price and Availability

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Camobucol, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524543
Name: Camobucol
CAS#: 216167-92-9
Chemical Formula: C33H50O4S2
Exact Mass: 574.31505
Molecular Weight: 574.88
Elemental Analysis: C, 68.95; H, 8.77; O, 11.13; S, 11.16


Synonym: Camobucol; UNII-FZ7798X3IR; Camobucol (USAN/INN); FZ7798X3IR; SCHEMBL4734553.

IUPAC/Chemical Name: 2-(2,6-di-tert-butyl-4-((2-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)propan-2-yl)thio)phenoxy)acetic acid

InChi Key: FGBGXESDYFKUFX-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H50O4S2/c1-29(2,3)22-15-20(16-23(27(22)36)30(4,5)6)38-33(13,14)39-21-17-24(31(7,8)9)28(37-19-26(34)35)25(18-21)32(10,11)12/h15-18,36H,19H2,1-14H3,(H,34,35)

SMILES Code: CC(C)(C)c1cc(cc(c1O)C(C)(C)C)SC(C)(C)Sc2cc(c(c(c2)C(C)(C)C)OCC(=O)O)C(C)(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kunsch C, Luchoomun J, Chen XL, Dodd GL, Karu KS, Meng CQ, Marino EM, Olliff LK, Piper JD, Qiu FH, Sikorski JA, Somers PK, Suen KL, Thomas S, Whalen AM, Wasserman MA, Sundell CL. AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]- 2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression. J Pharmacol Exp Ther. 2005 May;313(2):492-501. Epub 2005 Feb 8. PubMed PMID: 15701708.

2: Meng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDOnald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA. Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases. J Med Chem. 2004 Dec 2;47(25):6420-32. PubMed PMID: 15566311.