BMS-346567

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526647

CAS#: 953807-31-3

Description: BMS-346567 is apotent and selective dual angiotensin II and endothelin A receptor antagonist. BMS-346567 demonstrated superiority over irbesartan (an AT(1) receptor antagonist) in the normal SHR model of hypertension in a dose-dependent manner, demonstrating the synergy of AT(1) and ET(A) receptor blockade in a single molecule. Structurally, BMS-346567 is an analog of Sparsentan (RE-021 and PS433540).

Chemical Structure

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BMS-346567
CAS# 953807-31-3
Instruction

Theoretical Analysis

MedKoo Cat#: 526647
Name: BMS-346567
CAS#: 953807-31-3
Chemical Formula: C33H42N4O5S
Exact Mass: 606.29
Molecular Weight: 606.782
Elemental Analysis: C, 65.32; H, 6.98; N, 9.23; O, 13.18; S, 5.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BMS346567; BMS 346567; BMS-346567.

IUPAC/Chemical Name: 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.5]dec-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

InChi Key: CWMQUSPFWVHUGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H42N4O5S/c1-5-7-15-30-34-33(18-11-8-12-19-33)32(38)37(30)21-25-16-17-27(26(20-25)22-41-6-2)28-13-9-10-14-29(28)43(39,40)36-31-23(3)24(4)42-35-31/h9-10,13-14,16-17,20H,5-8,11-12,15,18-19,21-22H2,1-4H3,(H,35,36)

SMILES Code: CCCCC1=NC2(C(N1CC(C=C3COCC)=CC=C3C4=CC=CC=C4S(NC5=NOC(C)=C5C)(=O)=O)=O)CCCCC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 606.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM,
Monshizadegan H, Dickinson KE, Valentine MT, Humphreys WG, Lan SJ, Ewing WR,
Carlson KE, Kowala MC, Zahler R, Macor JE. Dual angiotensin II and endothelin A
receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl
biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005
Jan 13;48(1):171-9. PubMed PMID: 15634011.