MI-2 (MALT1 inhibitor)
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MedKoo CAT#: 407345

CAS#: 1047953-91-2

Description: MI-2 is a MALT1 inhibitor (IC50 = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-κB) activation, plays an important role in innate and adaptive immunity. Suppression of MALT1 protease activity with small molecule inhibitors showed promising efficacies in subtypes of B cell lymphoma and improvement in experimental autoimmune encephalomyelitis model.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
Size
Price

100mg
USD 750
1g
USD 2750
Size
Price

200mg
USD 1250
2g
USD 4650

MI-2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407345
Name: MI-2 (MALT1 inhibitor)
CAS#: 1047953-91-2
Chemical Formula: C19H17Cl3N4O3
Exact Mass: 454.0366
Molecular Weight: 455.72
Elemental Analysis: C, 50.08; H, 3.76; Cl, 23.34; N, 12.29; O, 10.53


Synonym: MI-2; MI 2; MI2.

IUPAC/Chemical Name: 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide

InChi Key: TWJGQZBSEMDPQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)

SMILES Code: O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liu W, Guo W, Hang N, Yang Y, Wu X, Shen Y, Cao J, Sun Y, Xu Q. MALT1
inhibitors prevent the development of DSS-induced experimental colitis in mice
via inhibiting NF-κB and NLRP3 inflammasome activation. Oncotarget. 2016 Apr 20.
doi: 10.18632/oncotarget.8867. [Epub ahead of print] PubMed PMID: 27105502.

2: Xin BT, Schimmack G, Du Y, Florea BI, van der Marel GA, Driessen C, Krappmann
D, Overkleeft HS. Development of new Malt1 inhibitors and probes. Bioorg Med
Chem. 2016 Mar 28. pii: S0968-0896(16)30191-2. doi: 10.1016/j.bmc.2016.03.035.
[Epub ahead of print] PubMed PMID: 27085674.

3: Li H, He H, Gong L, Fu M, Wang TT. Short Communication: Preferential Killing
of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor. AIDS Res Hum
Retroviruses. 2016 Feb;32(2):174-7. doi: 10.1089/AID.2015.0343. PubMed PMID:
26728103; PubMed Central PMCID: PMC4761853.

4: Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M,
Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA,
Glickman JF, Borden K, Wu H, Melnick A. MALT1 small molecule inhibitors
specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec
11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003. PubMed PMID: 23238016; PubMed
Central PMCID: PMC3984478.