KC7F2
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407344

CAS#: 927822-86-4

Description: KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis.


Price and Availability

Size
Price

100mg
USD 650
1g
USD 3250
Size
Price

200mg
USD 1050
2g
USD 4850
Size
Price

500mg
USD 1950
5g
USD 6850

KC7F2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407344
Name: KC7F2
CAS#: 927822-86-4
Chemical Formula: C16H16Cl4N2O4S4
Exact Mass: 567.8747
Molecular Weight: 570.354
Elemental Analysis: C, 33.69; H, 2.83; Cl, 24.86; N, 4.91; O, 11.22; S, 22.48


Synonym: KC7F2

IUPAC/Chemical Name: N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)

InChi Key: REQLACDIZMLXIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2

SMILES Code: ClC1=C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)C=C(Cl)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Huang X, He Z, Jiang X, Hou M, Tang Z, Zhen X, Liang Y, Ma J. Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway. PLoS One. 2016 Mar 14;11(3):e0151553. doi: 10.1371/journal.pone.0151553. eCollection 2016. PubMed PMID: 26974319; PubMed Central PMCID: PMC4790958.

2: Cheng CC, Guan SS, Yang HJ, Chang CC, Luo TY, Chang J, Ho AS. Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer. J Biomed Sci. 2016 Jan 28;23:18. doi: 10.1186/s12929-016-0219-6. PubMed PMID: 26822586; PubMed Central PMCID: PMC4730655.

3: Guan G, Zhang Y, Lu Y, Liu L, Shi D, Wen Y, Yang L, Ma Q, Liu T, Zhu X, Qiu X, Zhou Y. The HIF-1α/CXCR4 pathway supports hypoxia-induced metastasis of human osteosarcoma cells. Cancer Lett. 2015 Feb 1;357(1):254-64. doi: 10.1016/j.canlet.2014.11.034. Epub 2014 Nov 18. PubMed PMID: 25444927.

4: Li J, Jiang G, Chen Y, Chen L, Li Z, Wang Z, Wang X. Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. Synapse. 2014 Sep;68(9):402-9. doi: 10.1002/syn.21752. Epub 2014 Jun 17. PubMed PMID: 24889205.

5: Rathnasamy G, Ling EA, Kaur C. Hypoxia inducible factor-1α mediates iron uptake which induces inflammatory response in amoeboid microglial cells in developing periventricular white matter through MAP kinase pathway. Neuropharmacology. 2014 Feb;77:428-40. doi: 10.1016/j.neuropharm.2013.10.024. Epub 2013 Nov 1. PubMed PMID: 24184387.

6: Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res. 2009 Oct 1;15(19):6128-36. doi: 10.1158/1078-0432.CCR-08-3180. Epub 2009 Sep 29. PubMed PMID: 19789328; PubMed Central PMCID: PMC2770235.

7: Koh MY, Spivak-Kroizman TR, Powis G. Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin Cancer Res. 2009 Oct 1;15(19):5945-6. doi: 10.1158/1078-0432.CCR-09-1650. Epub 2009 Sep 29. PubMed PMID: 19789327; PubMed Central PMCID: PMC2760048.