BAY-41-8543

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524384

CAS#: 256498-66-5

Description: BAY-41-8543 is a NO-independent guanylyl cyclase stimulator. BAY 41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently.


Price and Availability

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BAY-41-8543, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524384
Name: BAY-41-8543
CAS#: 256498-66-5
Chemical Formula: C21H21FN8O
Exact Mass: 420.18224
Molecular Weight: 420.44
Elemental Analysis: C, 59.99; H, 5.03; F, 4.52; N, 26.65; O, 3.81


Synonym: BAY-41-8543; BAY418543; BAY41-8543; UNII-323T2C09SG;

IUPAC/Chemical Name: 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-5-morpholinopyrimidine-4,6-diamine

InChi Key: AQYFUZRYBJBAGZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21FN8O/c22-15-6-2-1-4-13(15)12-30-21-14(5-3-7-25-21)16(28-30)20-26-18(23)17(19(24)27-20)29-8-10-31-11-9-29/h1-7H,8-12H2,(H4,23,24,26,27)

SMILES Code: c1ccc(c(c1)Cn2c3c(cccn3)c(n2)c4nc(c(c(n4)N)N5CCOCC5)N)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Stancu B, Krämer S, Loof T, Mika A, Amann K, Neumayer HH, Peters H. Soluble guanylate cyclase stimulator BAY 41-8543 and female sex ameliorate uremic aortic remodeling in a rat model of mild uremia. J Hypertens. 2015 Sep;33(9):1907-20; discussion 1921. doi: 10.1097/HJH.0000000000000648. PubMed PMID: 26176653.

2: Watts JA, Gellar MA, Fulkerson MB, Kline JA. A soluble guanylate cyclase stimulator, BAY 41-8543, preserves right ventricular function in experimental pulmonary embolism. Pulm Pharmacol Ther. 2013 Apr;26(2):205-11. doi: 10.1016/j.pupt.2012.10.009. Epub 2012 Nov 7. PubMed PMID: 23142020.

3: Lasker GF, Pankey EA, Allain AV, Dhaliwal JS, Stasch JP, Murthy SN, Kadowitz PJ. Analysis of erectile responses to BAY 41-8543 and muscarinic receptor stimulation in the rat. J Sex Med. 2013 Mar;10(3):704-18. doi: 10.1111/j.1743-6109.2012.02912.x. Epub 2012 Sep 18. PubMed PMID: 22989320; PubMed Central PMCID: PMC3594361.

4: Watts JA, Gellar MA, Fulkerson MB, Kline JA. Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543. Crit Care Med. 2011 Dec;39(12):2700-4. doi: 10.1097/CCM.0b013e318226678e. PubMed PMID: 21705882.

5: Badejo AM Jr, Nossaman VE, Pankey EA, Bhartiya M, Kannadka CB, Murthy SN, Nossaman BD, Kadowitz PJ. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1153-9. doi: 10.1152/ajpheart.01101.2009. Epub 2010 Jul 16. PubMed PMID: 20639220; PubMed Central PMCID: PMC2957355.

6: Stasch JP, Dembowsky K, Perzborn E, Stahl E, Schramm M. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol. 2002 Jan;135(2):344-55. PubMed PMID: 11815369; PubMed Central PMCID: PMC1573146.

7: Stasch JP, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Minuth T, Perzborn E, Schramm M, Straub A. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br J Pharmacol. 2002 Jan;135(2):333-43. PubMed PMID: 11815368; PubMed Central PMCID: PMC1573147.