AZD-7325
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524351

CAS#: 942437-37-8

Description: AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.


Chemical Structure

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AZD-7325
CAS# 942437-37-8

Theoretical Analysis

MedKoo Cat#: 524351
Name: AZD-7325
CAS#: 942437-37-8
Chemical Formula: C19H19FN4O2
Exact Mass: 354.15
Molecular Weight: 354.380
Elemental Analysis: C, 64.40; H, 5.40; F, 5.36; N, 15.81; O, 9.03

Price and Availability

Size Price Availability Quantity
25mg USD 350 2 Weeks
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 7450 2 Weeks
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Related CAS #: 1252802-75-7 (hydrogen sulfate)  

Synonym: AZD-7325; AZD 7325; AZD7325.

IUPAC/Chemical Name: 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide

InChi Key: KYDURMHFWXCKMW-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)

SMILES Code: O=C(C1=NN=C2C(C3=C(OC)C=CC=C3F)=CC=CC2=C1N)NCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: Related: 942437-37-8 (AZD-7325) 1252802-75-7 (AZD-7325 hydrogen sulfate)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 354.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL. The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54. doi: 10.1002/cpdd.134. Epub 2014 Aug 28. PubMed PMID: 27128218.

2: Chen X, Jacobs G, de Kam M, Jaeger J, Lappalainen J, Maruff P, Smith MA, Cross AJ, Cohen A, van Gerven J. The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. doi: 10.1111/bcp.12413. PubMed PMID: 24802722; PubMed Central PMCID: PMC4256620.

3: Zhou D, Lu Z, Sunzel M, Xu H, Al-Huniti N. Population pharmacokinetic modelling to assess clinical drug-drug interaction between AZD7325 and midazolam. J Clin Pharm Ther. 2014 Aug;39(4):404-10. doi: 10.1111/jcpt.12152. Epub 2014 Apr 1. PubMed PMID: 24689515.

4: Zhou D, Sunzel M, Ribadeneira MD, Smith MA, Desai D, Lin J, Grimm SW. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison. Br J Clin Pharmacol. 2012 Jul;74(1):98-108. doi: 10.1111/j.1365-2125.2011.04155.x. PubMed PMID: 22122233; PubMed Central PMCID: PMC3394133.