Lysipressin Acetate
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MedKoo CAT#: 326649

CAS#: 83968-49-4

Description: Lysipressin Acetate is an analog of Vasopressin, a powerful vasopressor used to modulate blood pressure. An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action.


Chemical Structure

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Lysipressin Acetate
CAS# 83968-49-4

Theoretical Analysis

MedKoo Cat#: 326649
Name: Lysipressin Acetate
CAS#: 83968-49-4
Chemical Formula: C48H68N12O15S2
Exact Mass: 0.00
Molecular Weight: 1,117.261
Elemental Analysis: C, 51.60; H, 6.14; N, 15.04; O, 21.48; S, 5.74

Price and Availability

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10mg USD 385 2 Weeks
50mg USD 750 2 Weeks
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Related CAS #: 22049-37-2   50-57-7 (free base),  

Synonym: Lysipressin Acetate. L-Lysine vasopressin; Lypressin; Lysine pitressin; Lysine vasopressin; Lysine-ADH; Lysopressin; Lysylvasopressin; Oxytocin, 3-(L-phenylalanine)-8-L-lysine-; Postacton; Syntopressin; Vasophysin; Vasopressin-8-lysine; [8-Lysine]Vasopressin.

IUPAC/Chemical Name: H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond).

InChi Key: MSNBBKCTGMZLMA-DHSVNZEYSA-N

InChi Code: InChI=1S/C46H64N12O13S2.C2H4O2/c47-17-5-4-9-29(40(65)51-22-38(62)63)53-45(70)35-10-6-18-58(35)46(71)34-24-73-72-23-28(48)39(64)54-31(20-26-11-13-27(59)14-12-26)43(68)55-32(19-25-7-2-1-3-8-25)42(67)52-30(15-16-36(49)60)41(66)56-33(21-37(50)61)44(69)57-34;1-2(3)4/h1-3,7-8,11-14,28-35,59H,4-6,9-10,15-24,47-48H2,(H2,49,60)(H2,50,61)(H,51,65)(H,52,67)(H,53,70)(H,54,64)(H,55,68)(H,56,66)(H,57,69)(H,62,63);1H3,(H,3,4)/t28-,29-,30-,31-,32-,33-,34-,35-;/m0./s1

SMILES Code: O=C([C@@H](N)CSSC[C@H](NC1=O)C(N2[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CCC2)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4.CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Lysipressin Acetate is an analog of Vasopressin, a powerful vasopressor used to modulate blood pressure.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 89.50

Preparing Stock Solutions

The following data is based on the product molecular weight 1,117.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Rouille Y, Chauvet MT, Chauvet J, Acher R, Hadley ME. The distribution of lysine vasopressin (lysipressin) in placental mammals: a reinvestigation of the Hippopotamidae (Hippopotamus amphibius) and Tayassuidae (Tayassu angulatus) families. Gen Comp Endocrinol. 1988 Sep;71(3):475-83. PubMed PMID: 3192070.

2: Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. Review. PubMed PMID: 3147712.

3: Rouillé Y, Chauvet MT, Chauvet J, Acher R. Dual duplication of neurohypophysial hormones in an Australian marsupial: mesotocin, oxytocin, lysine vasopressin and arginine vasopressin in a single gland of the northern bandicoot (Isoodon macrourus). Biochem Biophys Res Commun. 1988 Jul 15;154(1):346-50. PubMed PMID: 3395337.

4: Chauvet J, Rouille Y, Chauvet MT, Acher R. Evolution of marsupials traced by their neurohypophyseal hormones: microidentification of mesotocin and arginine vasopressin in two Australian families, Dasyuridae and Phascolarctidae. Gen Comp Endocrinol. 1987 Sep;67(3):399-408. PubMed PMID: 3666414.

5: Acher R. The nonmammalian-mammalian transition through neurohypophysial peptides. Peptides. 1985;6 Suppl 3:309-14. PubMed PMID: 3831965.

6: Chauvet J, Hurpet D, Michel G, Chauvet MT, Acher R. Two multigene families for marsupial neurohypophysial hormones? Identification of oxytocin, mesotocin, lysipressin and arginine vasopressin in the North American opossum (Didelphis virginiana). Biochem Biophys Res Commun. 1984 Aug 30;123(1):306-11. PubMed PMID: 6477584.

7: Chauvet MT, Colne T, Hurpet D, Chauvet J, Acher R. A multigene family for the vasopressin-like hormones? Identification of mesotocin, lysipressin and phenypressin in Australian macropods. Biochem Biophys Res Commun. 1983 Oct 14;116(1):258-63. PubMed PMID: 6639661.