AZD-1305

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524331

CAS#: 872045-91-5

Description: AZD1305 is an experimental drug candidate that is under investigation for the management and reversal of cardiac arrhythmias.


Chemical Structure

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AZD-1305
CAS# 872045-91-5

Theoretical Analysis

MedKoo Cat#: 524331
Name: AZD-1305
CAS#: 872045-91-5
Chemical Formula: C22H31FN4O4
Exact Mass: 434.23
Molecular Weight: 434.500
Elemental Analysis: C, 60.81; H, 7.19; F, 4.37; N, 12.89; O, 14.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AZD-1305; AZD 1305; AZD1305;

IUPAC/Chemical Name: (2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester

InChi Key: BLLNYXOLLAVTRF-HDICACEKSA-N

InChi Code: InChI=1S/C22H31FN4O4/c1-22(2,3)31-21(28)25-6-7-26-12-17-14-27(15-18(13-26)30-17)8-9-29-20-5-4-16(11-24)10-19(20)23/h4-5,10,17-18H,6-9,12-15H2,1-3H3,(H,25,28)/t17-,18+

SMILES Code: CC(C)(C)OC(=O)NCCN1C[C@@H]2CN(C[C@H](C1)O2)CCOc3ccc(cc3F)C#N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 434.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sigfridsson K, Lundqvist R, Ohlson K. Preformulation evaluation of AZD1305, an oxabispidine intended for oral and intravenous treatment. Drug Dev Ind Pharm. 2012 Jan;38(1):19-31. doi: 10.3109/03639045.2011.589452. Epub 2011 Jun 27. PubMed PMID: 21707325.

2: Johnson DM, de Jong MM, Crijns HJ, Carlsson LG, Volders PG. Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9. doi: 10.1161/CIRCEP.111.963025. Epub 2011 Nov 11. PubMed PMID: 22080293.