AZD-0328
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524324

CAS#: 220099-91-2

Description: AZD 0328 is an alpha7 neuronal nicotinic receptor agonist.

Chemical Structure

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AZD-0328
CAS# 220099-91-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 524324
Name: AZD-0328
CAS#: 220099-91-2
Chemical Formula: C13H16N2O
Exact Mass: 216.13
Molecular Weight: 216.280
Elemental Analysis: C, 72.19; H, 7.46; N, 12.95; O, 7.40

Price and Availability

Size Price Availability Quantity
1mg USD 150 Ready to Ship
5mg USD 450 Ready to Ship
10mg USD 750 Ready to Ship
25mg USD 1450 Ready to Ship
50mg USD 2450 Ready to Ship
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Synonym: AZD 0328; AZD-0328; AZD0328;

IUPAC/Chemical Name: Spiro[1-azabicyclo[2.2.2]octane-3,2′(3′H)-furo[2,3-b]pyridine], (2′R)-

InChi Key: OCKIPDMKGPYYJS-ZDUSSCGKSA-N

InChi Code: InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1

SMILES Code: [C@]12(C3CCN(C1)CC3)CC=4C(O2)=NC=CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: AZD-0328 is a selective α7 nicotinic receptor agonist that enhances cortical dopamine release and improves learning and attentional processes in rats.
In vitro activity: AZD-0328 showed stability in human hepatocyte incubations but underwent extensive metabolism in other species. Primary metabolites included the N-oxidation metabolite (M6) and an N-glucuronide metabolite in human liver microsomes. Various preclinical species displayed additional metabolic pathways. Reference: Xenobiotica. 2011 Mar;41(3):232-42. https://pubmed.ncbi.nlm.nih.gov/21226652/
In vivo activity: AZD-0328 may hold therapeutic promise for conditions characterized by cognitive deficits and dopamine neuron dysfunction in neurologic and psychiatric contexts. In rat brain recordings, AZD-0328 increased the firing of putative dopamine neurons in the ventral tegmental area. In awake rats, AZD-0328 led to elevated prefrontal cortical dopamine levels. AZD-0328 improved operant responding with delayed reinforcement in rats and enhanced novel object recognition in mice. Reference: Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. https://pubmed.ncbi.nlm.nih.gov/19615981/

Preparing Stock Solutions

The following data is based on the product molecular weight 216.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Zhou D, Zhang M, Ye X, Gu C, Piser TM, Lanoue BA, Schock SA, Cheng YF, Grimm SW. In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite. Xenobiotica. 2011 Mar;41(3):232-42. doi: 10.3109/00498254.2010.536855. Epub 2011 Jan 13. PMID: 21226652. 2. Ding M, Ghanekar S, Elmore CS, Zysk JR, Werkheiser JL, Lee CM, Liu J, Chhajlani V, Maier DL. [³H]Chiba-1001(methyl-SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha-7 receptor in rodent brain. Synapse. 2012 Apr;66(4):315-22. doi: 10.1002/syn.21513. Epub 2011 Dec 29. PMID: 22108786. 3. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16. PMID: 19615981. 4. Castner SA, Smagin GN, Piser TM, Wang Y, Smith JS, Christian EP, Mrzljak L, Williams GV. Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry. 2011 Jan 1;69(1):12-8. doi: 10.1016/j.biopsych.2010.08.006. Epub 2010 Oct 20. PMID: 20965497.
In vitro protocol: 1. Zhou D, Zhang M, Ye X, Gu C, Piser TM, Lanoue BA, Schock SA, Cheng YF, Grimm SW. In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite. Xenobiotica. 2011 Mar;41(3):232-42. doi: 10.3109/00498254.2010.536855. Epub 2011 Jan 13. PMID: 21226652. 2. Ding M, Ghanekar S, Elmore CS, Zysk JR, Werkheiser JL, Lee CM, Liu J, Chhajlani V, Maier DL. [³H]Chiba-1001(methyl-SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha-7 receptor in rodent brain. Synapse. 2012 Apr;66(4):315-22. doi: 10.1002/syn.21513. Epub 2011 Dec 29. PMID: 22108786.
In vivo protocol: 1. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16. PMID: 19615981. 2. Castner SA, Smagin GN, Piser TM, Wang Y, Smith JS, Christian EP, Mrzljak L, Williams GV. Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry. 2011 Jan 1;69(1):12-8. doi: 10.1016/j.biopsych.2010.08.006. Epub 2010 Oct 20. PMID: 20965497.

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1: Zhou D, Zhang M, Ye X, Gu C, Piser TM, Lanoue BA, Schock SA, Cheng YF, Grimm SW. In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite. Xenobiotica. 2011 Mar;41(3):232-42. doi: 10.3109/00498254.2010.536855. Epub 2011 Jan 13. PubMed PMID: 21226652.

2: Castner SA, Smagin GN, Piser TM, Wang Y, Smith JS, Christian EP, Mrzljak L, Williams GV. Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry. 2011 Jan 1;69(1):12-8. doi: 10.1016/j.biopsych.2010.08.006. Epub 2010 Oct 20. PubMed PMID: 20965497.

3: Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16. PubMed PMID: 19615981.