Fludalanine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326634

CAS#: 35523-45-6

Description: Fludalanine, also known as MK641, is an analogue of D-alanine that irreversibly inactivates the racemase. Fludalanine inhibits the synthetase. When combined with cycloserine, it has been found to be more active against a wide range of non-mycobacterial organisms than either fludalanine or cycloserine alone.

Chemical Structure

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Fludalanine
CAS# 35523-45-6
Instruction

Theoretical Analysis

MedKoo Cat#: 326634
Name: Fludalanine
CAS#: 35523-45-6
Chemical Formula: C3H5DFNO2
Exact Mass: 108.04
Molecular Weight: 108.091
Elemental Analysis: C, 33.34; H, 6.53; F, 17.58; N, 12.96; O, 29.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MK641; MK641; MK641; Fludalanine; 3-Fluoro-D-(2-2H)alanine; D-Alanine-2-d, 3-fluoro-.

IUPAC/Chemical Name: (S)-2-amino-3-fluoropropanoic-2-d acid

InChi Key: UYTSRQMXRROFPU-LIIDHCAMSA-N

InChi Code: InChI=1S/C3H6FNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m1/s1/i2D

SMILES Code: N[C@@](CF)([2H])C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 108.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Musson DG, Maglietto SM, Hwang SS, Gravellese D, Bayne WF. Simultaneous
quantification of cycloserine and its prodrug acetylacetonylcycloserine in plasma
and urine by high-performance liquid chromatography using ultraviolet absorbance
and fluorescence after post-column derivatization. J Chromatogr. 1987 Feb
20;414(1):121-9. PubMed PMID: 3571377.


2: Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ. Oxidative
and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Drug Metab
Dispos. 1986 Nov-Dec;14(6):668-73. PubMed PMID: 2877824.


3: Dickinson JM, Mitchison DA. Activity of the combination of fludalanine and
cycloserine against mycobacteria in vitro. Tubercle. 1985 Jun;66(2):109-15.
PubMed PMID: 4024268.


4: Musson DG, Maglietto SM, Bayne WF. Determination of the antibiotic fludalanine
in plasma and urine by high-performance liquid chromatography using a packed-bed,
post-column reactor with o-phthalaldehyde and 2-mercaptoethanol. J Chromatogr.
1985 Mar 22;338(2):357-67. PubMed PMID: 3998023.


5: Wise R, Andrews JM. In vitro activity of fludalanine combined with pentizidone
compared with those of other agents. Antimicrob Agents Chemother. 1984
May;25(5):612-7. PubMed PMID: 6610389; PubMed Central PMCID: PMC185598.


6: Esposito AL, Pennington JE. Experimental pneumonia due to Haemophilus
influenzae: observations on pathogenesis and treatment. J Infect Dis. 1984
May;149(5):728-34. PubMed PMID: 6610002.