Benzhexol HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318909

CAS#: 144-11-6

Description: Benzhexol HCl, also known as Trihexyphenidyl, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades.


Price and Availability

Size
Price

1g
USD 190
Size
Price

2g
USD 350
Size
Price

5g
USD 650

Benzhexol HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318909
Name: Benzhexol HCl
CAS#: 144-11-6
Chemical Formula: C20H32ClNO
Exact Mass: 301.2406
Molecular Weight: 337.932
Elemental Analysis: C, 71.09; H, 9.55; Cl, 10.49; N, 4.14; O, 4.73


Related CAS #: 52-49-3 (HCl)    

Synonym: Trihexyphenidyl, Benzhexol, Trihex, Artane, Apo-Trihex, Parkin, Pacitane; Benzhexol HCl

IUPAC/Chemical Name: 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride

InChi Key: QDWJJTJNXAKQKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

SMILES Code: OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCCC3.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lee CP, Chen PJ, Chang CM. Heat stroke during treatment with olanzapine, trihexyphenidyl, and trazodone in a patient with schizophrenia. Acta Neuropsychiatr. 2015 Dec;27(6):380-5. doi: 10.1017/neu.2015.29. PubMed PMID: 26503496.

2: Begbie F, Walker G, Kubba H, Sabharwal A. Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. Int J Pediatr Otorhinolaryngol. 2015 Jun;79(6):932-4. doi: 10.1016/j.ijporl.2015.03.027. Epub 2015 Apr 7. PubMed PMID: 25912627.

3: Saito T, Katayama T, Sawada J, Kano K, Asanome A, Takahashi K, Sato N, Hasebe N. Combination therapy for segmental craniocervical dystonia (Meige syndrome) with aripiprazole, trihexyphenidyl, and botulinum toxin: three cases reports. Neurol Sci. 2015 Feb;36(2):243-5. doi: 10.1007/s10072-014-1927-x. Epub 2014 Aug 24. PubMed PMID: 25151364.

4: Maeda H, Tanaka R, Nakayama H. Inclusion complexes of trihexyphenidyl with natural and modified cyclodextrins. Springerplus. 2015 May 7;4:218. doi: 10.1186/s40064-015-0986-7. eCollection 2015. PubMed PMID: 26020020; PubMed Central PMCID: PMC4439407.

5: Shioya A, Tomidokoro Y, Ishii K, Ishii A, Tamaoka A. [Case report: a case of anterocollis ameliorated by trihexyphenidyl]. Nihon Naika Gakkai Zasshi. 2011 Nov 10;100(11):3325-8. Japanese. PubMed PMID: 22250425.

6: Robottom BJ, Reich SG. Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review. Neurologist. 2011 Nov;17(6):340-1. doi: 10.1097/NRL.0b013e31822b54d2. PubMed PMID: 22045287.

7: Petković S, Durendić-Brenesel M, Dolai M, Samojlik I. Fatal intoxication because of trihexyphenidyl. J Forensic Sci. 2011 Sep;56(5):1383-6. doi: 10.1111/j.1556-4029.2011.01816.x. Epub 2011 Jun 3. PubMed PMID: 21644988.

8: Zheng SQ, Wang W, Liang C, Wang R, Gong FJ, Wu ZP, Chen YS, Zhang YR, Zhang RS. [Simultaneous determination of trihexyphenidyl, chlorpromazine and clozapine in blood by GC-MS]. Fa Yi Xue Za Zhi. 2011 Aug;27(4):271-3. Chinese. PubMed PMID: 21913556.

9: Ben-Pazi H. Trihexyphenidyl improves motor function in children with dystonic cerebral palsy: a retrospective analysis. J Child Neurol. 2011 Jul;26(7):810-6. doi: 10.1177/0883073810392582. Epub 2011 Apr 15. PubMed PMID: 21498790.

10: Carranza-del Rio J, Clegg NJ, Moore A, Delgado MR. Use of trihexyphenidyl in children with cerebral palsy. Pediatr Neurol. 2011 Mar;44(3):202-6. doi: 10.1016/j.pediatrneurol.2010.09.008. PubMed PMID: 21310336.

11: De Rinaldis M, Gennaro L, Losito L, Trabacca A. Drug-to-drug interaction between sodium valproate and trihexyphenidyl in a child with extrapyramidal cerebral palsy and epilepsy. Eur J Clin Pharmacol. 2011 Mar;67(3):315-6. doi: 10.1007/s00228-010-0918-y. Epub 2010 Oct 20. PubMed PMID: 20959970.

12: Liu ZZ, Ji BS. The protective effect of trihexyphenidyl on the beta-amyloid peptide (25-35)-induced cytotoxicity in PC12 cells. Clin Exp Med. 2010 Dec;10(4):237-43. doi: 10.1007/s10238-010-0090-9. Epub 2010 Jan 26. PubMed PMID: 20101432.

13: Maccaroni E, Malpezzi L, Masciocchi N. Trihexyphenidyl hydro-chloride: a powder diffraction study. Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 4;66(Pt 10):o2511. doi: 10.1107/S1600536810035294. PubMed PMID: 21587506; PubMed Central PMCID: PMC2983296.

14: Pomara N, Yi L, Belzer K, Facelle TM, Willoughby LM, Sidtis JJ. Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 allele. Eur Neuropsychopharmacol. 2010 Jul;20(7):467-72. doi: 10.1016/j.euroneuro.2010.03.004. Epub 2010 Apr 22. PubMed PMID: 20417063.

15: Wate SP, Borkar AA. Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets. Indian J Pharm Sci. 2010 Mar;72(2):265-7. doi: 10.4103/0250-474X.65016. PubMed PMID: 20838539; PubMed Central PMCID: PMC2929794.

16: Gika AD, Hughes E, Goyal S, Sparkes M, Lin JP. Trihexyphenidyl for acute life-threatening episodes due to a dystonic movement disorder in Rett syndrome. Mov Disord. 2010 Feb 15;25(3):385-9. doi: 10.1002/mds.22926. PubMed PMID: 20063434.

17: Praharaj SK, Sarkhel S, Khanande RV, Sinha VK. Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl. Psychopharmacol Bull. 2010;43(4):73-5. PubMed PMID: 21240153.

18: Aggarwal A, Garg A, Jiloha RC. Trihexyphenidyl (benzhexol) in clozapine-induced nocturnal enuresis and sialorrhea. Indian J Med Sci. 2009 Oct;63(10):470-1. doi: 10.4103/0019-5359.57642. PubMed PMID: 19901488.

19: Rice J, Waugh MC. Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. J Child Neurol. 2009 Feb;24(2):176-82. doi: 10.1177/0883073808322668. PubMed PMID: 19182155.

20: Appendino JP, Soman T. Correspondence on "Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy". J Child Neurol. 2008 Jul;23(7):846; author reply 846-7. doi: 10.1177/0883073808316369. PubMed PMID: 18658086.