WEHI-345
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526614

CAS#: 1354825-58-3

Description: WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.


Price and Availability

Size
Price

10mg
USD 190
100mg
USD 950
1g
USD 3350
Size
Price

25mg
USD 380
200mg
USD 1650
2g
USD 4950
Size
Price

50mg
USD 650
500mg
USD 2250
5g
USD 7850

WEHI-345, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Note: the estimated shipping out time for order >200mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526614
Name: WEHI-345
CAS#: 1354825-58-3
Chemical Formula: C22H23N7O
Exact Mass: 401.1964
Molecular Weight: 401.474
Elemental Analysis: C, 65.82; H, 5.77; N, 24.42; O, 3.99


Synonym: WEHI-345; WEHI345; WEHI 345.

IUPAC/Chemical Name: N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropyl)isonicotinamide

InChi Key: LEBSTCDZKUSVOY-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23N7O/c1-14-4-6-15(7-5-14)18-17-19(23)26-13-27-20(17)29(28-18)22(2,3)12-25-21(30)16-8-10-24-11-9-16/h4-11,13H,12H2,1-3H3,(H,25,30)(H2,23,26,27)

SMILES Code: O=C(NCC(C)(N1N=C(C2=CC=C(C)C=C2)C3=C(N)N=CN=C31)C)C4=CC=NC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham
Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP,
Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M,
Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J. A RIPK2 inhibitor
delays NOD signalling events yet prevents inflammatory cytokine production. Nat
Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442. PubMed PMID: 25778803.