WAY-181187
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MedKoo CAT#: 522997

CAS#: 554403-49-5

Description: WAY-181187 is a potent and selective 5-HT6 receptor agonist. WAY-181187 possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of WAY-181187 (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.


Price and Availability

Size
Price

10mg
Not available
100mg
USD 950
1g
USD 3250
Size
Price

25mg
Not available
200mg
USD 1650
2g
USD 4650
Size
Price

50mg
Not available
500mg
USD 2650
5g
Ask price

WAY-181187, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522997
Name: WAY-181187
CAS#: 554403-49-5
Chemical Formula: C15H13ClN4O2S2
Exact Mass: 380.0168
Molecular Weight: 380.865
Elemental Analysis: C, 47.30; H, 3.44; Cl, 9.31; N, 14.71; O, 8.40; S, 16.84


Synonym: WAY-181187; WAY 181187; WAY181187

IUPAC/Chemical Name: 2-(1-((6-Chloroimidazo(2,1-b)(1,3)thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethylamine

InChi Key: RYBOXBBYCVOYNO-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2

SMILES Code: NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Brouard JT, Schweimer JV, Houlton R, Burnham KE, Quérée P, Sharp T. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS Chem Neurosci. 2015 Jul 15;6(7):1241-7. doi: 10.1021/acschemneuro.5b00061. Epub 2015 Apr 10. PubMed PMID: 25837696.

2: Borsini F, Bordi F, Poggi A, Di Matteo V. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J Psychopharmacol. 2015 Jul;29(7):802-11. doi: 10.1177/0269881115573804. Epub 2015 Mar 3. PubMed PMID: 25735994.

3: Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, Borsini F, Pisani A, Bonsi P. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011 Sep;61(4):632-7. doi: 10.1016/j.neuropharm.2011.05.004. Epub 2011 May 19. PubMed PMID: 21619890.

4: Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, Tarzia G, Rhim H, Borsini F. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. doi: 10.1016/j.ejphar.2011.04.028. Epub 2011 Apr 28. PubMed PMID: 21549693.

5: Rogóż Z, Gołembiowska K. Effect of metyrapone on the fluoxetine-induced change in extracellular dopamine, serotonin and their metabolites in the rat frontal cortex. Pharmacol Rep. 2010 Nov-Dec;62(6):1015-22. PubMed PMID: 21273658.

6: Fijał K, Pachuta A, McCreary AC, Wydra K, Nowak E, Papp M, Bieńkowski P, Kotlińska J, Filip M. Effects of serotonin (5-HT)6 receptor ligands on responding for cocaine reward and seeking in rats. Pharmacol Rep. 2010 Nov-Dec;62(6):1005-14. PubMed PMID: 21273657.

7: Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl). 2011 Feb;213(2-3):499-507. doi: 10.1007/s00213-010-1798-7. Epub 2010 Mar 9. PubMed PMID: 20217056; PubMed Central PMCID: PMC2910165.

8: Burnham KE, Baxter MG, Bainton JR, Southam E, Dawson LA, Bannerman DM, Sharp T. Activation of 5-HT(6) receptors facilitates attentional set shifting. Psychopharmacology (Berl). 2010 Jan;208(1):13-21. doi: 10.1007/s00213-009-1701-6. Epub 2009 Nov 10. PubMed PMID: 19902184.

9: West PJ, Marcy VR, Marino MJ, Schaffhauser H. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. 2009 Dec 1;164(2):692-701. doi: 10.1016/j.neuroscience.2009.07.061. Epub 2009 Aug 4. PubMed PMID: 19660530.

10: Cole DC, Stock JR, Lennox WJ, Bernotas RC, Ellingboe JW, Boikess S, Coupet J, Smith DL, Leung L, Zhang GM, Feng X, Kelly MF, Galante R, Huang P, Dawson LA, Marquis K, Rosenzweig-Lipson S, Beyer CE, Schechter LE. Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19. PubMed PMID: 17948978.

11: Loiseau F, Dekeyne A, Millan MJ. Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology (Berl). 2008 Jan;196(1):93-104. Epub 2007 Oct 6. PubMed PMID: 17922111.

12: Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R, Robichaud A, Rosenzweig-Lipson S, Beyer CE. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. Epub 2007 Jul 11. PubMed PMID: 17625499.