Sildenafil Citrate
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MedKoo CAT#: 318693

CAS#: 171599-83-0 (citrate)

Description: Sildenafil, Citrate is a citrate form of Sildenafil. Sildenafil is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.


Price and Availability

Size
Price

100mg
USD 70
1g
USD 450
10g
USD 1250
100g
USD 4950
Size
Price

200mg
USD 120
2g
USD 650
20g
USD 2150
200g
USD 6750
Size
Price

500mg
USD 250
5g
USD 850
50g
USD 3850
500g
Ask price

Sildenafil Citrate, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international). .


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318693
Name: Sildenafil Citrate
CAS#: 171599-83-0 (citrate)
Chemical Formula: C6H8O7
Exact Mass:
Molecular Weight: 192.12
Elemental Analysis: C, 37.51; H, 4.20; O, 58.29


Synonym: Sildenafil Citrate; UK 92480-10; UK-92,480-10. Trade name: Revatio; VIAGRA.

IUPAC/Chemical Name: 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate

SMILES Code: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
CAS#139755-83-2 (Sildenafil [INN:BAN])


References

1: Badr-Eldin SM, Ahmed OA. Optimized nano-transfersomal films for enhanced
sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation. Drug Des
Devel Ther. 2016 Apr 5;10:1323-33. doi: 10.2147/DDDT.S103122. eCollection 2016.
PubMed PMID: 27103786; PubMed Central PMCID: PMC4827598.

2: Bai WJ, Li HJ, Jin JJ, Xu WP, Sebastian S, Wang XF. A randomized clinical
trial investigating treatment choice in Chinese men receiving sildenafil citrate
and tadalafil for treating erectile dysfunction. Asian J Androl. 2016 Apr 22.
doi: 10.4103/1008-682X.175782. [Epub ahead of print] PubMed PMID: 27101805.

3: Luna RL, Vasconcelos AG, Santana Nunes AK, de Oliveira WH, Barbosa KP, Peixoto
CA. Effects of Sildenafil Citrate and Heparin Treatments on Placental Cell
Morphology in a Murine Model of Pregnancy Loss. Cells Tissues Organs.
2016;201(3):193-202. doi: 10.1159/000444123. Epub 2016 Mar 16. PubMed PMID:
26978649.

4: Shokeir AA, Tharwat MA, Abolazm AE, Harraz A. Sildenafil citrate as a medical
expulsive therapy for distal ureteric stones: A randomised double-blind
placebo-controlled study. Arab J Urol. 2016 Mar;14(1):1-6. doi:
10.1016/j.aju.2015.12.001. Epub 2016 Jan 21. PubMed PMID: 26966585; PubMed
Central PMCID: PMC4767793.

5: Dadey E. Bioequivalence of 2 Formulations of Sildenafil Oral Soluble Film 100
mg and Sildenafil Citrate (Viagra) 100 mg Oral Tablets in Healthy Male
Volunteers. Am J Ther. 2015 Jul 4. [Epub ahead of print] PubMed PMID: 26938750.

6: Sae Yoon A, Sawatdee S, Woradechakul C, Sae Chee K, Atipairin A.
Physicochemical and Microbiological Stability of the Extemporaneous Sildenafil
Citrate Oral Suspension. Sci Pharm. 2015 Jul 7;83(4):659-70. doi:
10.3797/scipharm.1505-08. eCollection 2015. PubMed PMID: 26839846; PubMed Central
PMCID: PMC4727739.

7: Lu X, Han H, Xing N, Tian L. [Efficacy of sildenafil citrate in men with
erectile dysfunction following bilateral nerve-sparing radical prostatectomy:
systematic review and meta-analysis]. Zhonghua Yi Xue Za Zhi. 2015 Sep
22;95(36):2964-8. Review. Chinese. PubMed PMID: 26814076.

8: Custers D, Krakowska B, De Beer JO, Courselle P, Daszykowski M, Apers S,
Deconinck E. Testing of complementarity of PDA and MS detectors using
chromatographic fingerprinting of genuine and counterfeit samples containing
sildenafil citrate. Anal Bioanal Chem. 2016 Feb;408(6):1643-56. doi:
10.1007/s00216-015-9275-0. Epub 2016 Jan 11. PubMed PMID: 26753972.

9: Korneev IA. [SILDENAFIL CITRATE DOSE ADJUSTMENT FOR MEN WITH ERECTILE
DYSFUNCTION: PERSONALIZED APPROACH]. Urologiia. 2015 Jul-Aug;(4):108, 110-1.
Russian. PubMed PMID: 26665776.

10: Kim DJ, Hawksworth DJ, Hurwitz LM, Cullen J, Rosner IL, Lue TF, Dean RC. A
prospective, randomized, placebo-controlled trial of on-Demand vs. nightly
sildenafil citrate as assessed by Rigiscan and the international index of
erectile function. Andrology. 2016 Jan;4(1):27-32. doi: 10.1111/andr.12118. Epub
2015 Dec 10. PubMed PMID: 26663669.

11: Sawatdee S, Pakawatchai C, Nitichai K, Srichana T, Phetmung H. Why sildenafil
and sildenafil citrate monohydrate crystals are not stable? Saudi Pharm J. 2015
Oct;23(5):504-14. doi: 10.1016/j.jsps.2015.01.019. Epub 2015 Jan 24. PubMed PMID:
26594116; PubMed Central PMCID: PMC4605910.

12: Tripathi AS, Timiri AK, Mazumder PM, Chandewar A. Does glimepiride alter the
pharmacokinetics of sildenafil citrate in diabetic nephropathy animals:
investigating mechanism of interaction by molecular modeling studies. J Mol
Model. 2015 Oct;21(10):276. doi: 10.1007/s00894-015-2823-x. Epub 2015 Oct 1.
PubMed PMID: 26428531.

13: Agrawal P, Soni S, Mittal G, Bhatnagar A. Preclinical safety evaluation of
submicronized sildenafil citrate nebulization solution in small experimental
animals. Exp Lung Res. 2015;41(8):450-8. doi: 10.3109/01902148.2015.1064492.
PubMed PMID: 26381717.

14: Ohams M, Jerzak M, Górski A. Effects of sildenafil citrate and etanercept
treatment on TNF-α levels in peripheral blood of women with recurrent
miscarriage. Ginekol Pol. 2015 Jul;86(7):520-4. PubMed PMID: 26376530.

15: Kellihan HB, Waller KR, Pinkos A, Steinberg H, Bates ML. Acute resolution of
pulmonary alveolar infiltrates in 10 dogs with pulmonary hypertension treated
with sildenafil citrate: 2005-2014. J Vet Cardiol. 2015 Sep;17(3):182-91. doi:
10.1016/j.jvc.2015.04.002. Epub 2015 Aug 17. PubMed PMID: 26293206.

16: Trapani AJ, Gonçalves LF, Trapani TF, Franco MJ, Galluzzo RN, Pires MM.
Comparison between transdermal nitroglycerin and sildenafil citrate in
intrauterine growth restriction: effect on uterine, umbilical and fetal middle
cerebral artery pulsatility index. Ultrasound Obstet Gynecol. 2015 Aug 17. doi:
10.1002/uog.15673. [Epub ahead of print] PubMed PMID: 26279411.

17: Kirilmaz U, Guzel O, Aslan Y, Balci M, Tuncel A, Atan A. The effect of
lifestyle modification and glycemic control on the efficiency of sildenafil
citrate in patients with erectile dysfunction due to type-2 diabetes mellitus.
Aging Male. 2015;18(4):244-8. doi: 10.3109/13685538.2015.1072154. Epub 2015 Aug
6. PubMed PMID: 26248034.

18: Efremov EA, Kasatonova EV, Mel'nik JI. [USE OF SILDENAFIL CITRATE FOR
TREATMENT OF ERECTILE DYSFUNCTION OF VARIOUS ETIOLOGY]. Urologiia. 2015
Mar-Apr;(2):117-8, 120-1. Review. Russian. PubMed PMID: 26237819.

19: Zeinalzadeh S, Akbarzadeh M, Mohagheghzadeh A, Faridi P, Sayadi M. Comparison
of the Effects of Elaeagnus angustifolia Flower Capsule and Sildenafil Citrate
Tablet on Anxiety Resulting From Sexual Dysfunction in Women Referring to the
Selected Clinics of Shiraz University of Medical Sciences. J Evid Based
Complementary Altern Med. 2015 Jul 28. pii: 2156587215595777. [Epub ahead of
print] PubMed PMID: 26224722.

20: Zilli T, Miralbell R. Re: Prophylactic Sildenafil Citrate Improves Select
Aspects of Sexual Function in Men Treated with Radiotherapy for Prostate Cancer:
M. J. Zelefsky, D. Shasha, R. D. Branco, M. Kollmeier, R. E. Baser, X. Pei, R.
Ennis, R. Stock, N. Bar-Chama and J. P. Mulhall J Urol 2014; 192: 868-874. J
Urol. 2015 Aug;194(2):600-1. doi: 10.1016/j.juro.2014.12.104. Epub 2015 May 7.
PubMed PMID: 25958020.