Salbutamol
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MedKoo CAT#: 318682

CAS#: 18559-94-9 (free base)

Description: Salbutamol is a β2-AR agonist. Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.


Chemical Structure

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Salbutamol
CAS# 18559-94-9 (free base)

Theoretical Analysis

MedKoo Cat#: 318682
Name: Salbutamol
CAS#: 18559-94-9 (free base)
Chemical Formula: C13H21NO3
Exact Mass: 239.15
Molecular Weight: 239.310
Elemental Analysis: C, 65.25; H, 8.84; N, 5.85; O, 20.06

Price and Availability

Size Price Availability Quantity
100mg USD 150
200mg USD 250
500mg USD 450
1g USD 650
2g USD 950
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Related CAS #: 51022-70-9 (sulfate)   18559-94-9 (free base)   51293-66-4 (HCl)    

Synonym: Salbutamol; Albuterol; Proventil; Sultanol; Aerolin; Albuterol Sulfate; Proventil; Salbutamol; Sultanol; Ventolin;

IUPAC/Chemical Name: 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

InChi Key: NDAUXUAQIAJITI-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3

SMILES Code: CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist that is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
In vitro activity: This study suggests that that salbutamol could be an effective adjuvant drug for the treatment of metastatic breast cancer. In IBH-6 and MDA-MB-231 cell lines, salbutamol significantly diminished cell migration. Also, salbutamol inhibited invasion of both breast cancer cell lines and enhanced adhesion to extracellular matrix. Salbutamol treatment was also able to decrease the expression of pro-metastatic genes in MDA-MB-231 cells. Reference: Curr Cancer Drug Targets. 2017;17(8):756-766. https://pubmed.ncbi.nlm.nih.gov/28359245/
In vivo activity: Salbutamol treatment significantly improved muscle strength and muscle coordination, and increased lean muscle mass in diabetic rats. Feret's diameter and cross-sectional area of GN muscle were increased by Salbutamol treatment, indicating the amelioration in diabetic rat muscle. Salbutamol treatment resulted in the restoration of perturbed metabolites, including histidine-to-tyrosine, phenylalanine-to-tyrosine, and glutamate-to-glutamine ratios and succinate, sarcosine, and 3-hydroxybutyrate in diabetic rats. Reference: Pharmaceutics. 2023 Aug 8;15(8):2101. https://pubmed.ncbi.nlm.nih.gov/37631314/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 417.87

Preparing Stock Solutions

The following data is based on the product molecular weight 239.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Mukherjee M, Cingolani E, Pritchard DI, Bosquillon C. Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma - Impact on salbutamol transport. Eur J Pharm Sci. 2017 Aug 30;106:62-70. doi: 10.1016/j.ejps.2017.05.052. Epub 2017 May 23. PMID: 28549677. 2. Rivero EM, Piñero CP, Gargiulo L, Entschladen F, Zänker K, Bruzzone A, Lüthy IA. The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line. Curr Cancer Drug Targets. 2017;17(8):756-766. doi: 10.2174/1568009617666170330151415. PMID: 28359245. 3. Kumar A, Prajapati P, Singh G, Kumar D, Mishra V, Kim SC, Raorane CJ, Raj V, Kushwaha S. Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. 2023 Aug 8;15(8):2101. doi: 10.3390/pharmaceutics15082101. PMID: 37631314; PMCID: PMC10458056. 4. Cardoso-Sousa L, Aguiar EMG, Caixeta DC, Vilela DD, Costa DPD, Silva TL, Cunha TM, Faria PR, Espindola FS, Jardim AC, Vieira AA, Oliveira TL, Goulart LR, Sabino-Silva R. Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis. PLoS One. 2019 Sep 19;14(9):e0222575. doi: 10.1371/journal.pone.0222575. PMID: 31536570; PMCID: PMC6752759.
In vitro protocol: 1. Mukherjee M, Cingolani E, Pritchard DI, Bosquillon C. Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma - Impact on salbutamol transport. Eur J Pharm Sci. 2017 Aug 30;106:62-70. doi: 10.1016/j.ejps.2017.05.052. Epub 2017 May 23. PMID: 28549677. 2. Rivero EM, Piñero CP, Gargiulo L, Entschladen F, Zänker K, Bruzzone A, Lüthy IA. The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line. Curr Cancer Drug Targets. 2017;17(8):756-766. doi: 10.2174/1568009617666170330151415. PMID: 28359245.
In vivo protocol: 1. Kumar A, Prajapati P, Singh G, Kumar D, Mishra V, Kim SC, Raorane CJ, Raj V, Kushwaha S. Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. 2023 Aug 8;15(8):2101. doi: 10.3390/pharmaceutics15082101. PMID: 37631314; PMCID: PMC10458056. 2. Cardoso-Sousa L, Aguiar EMG, Caixeta DC, Vilela DD, Costa DPD, Silva TL, Cunha TM, Faria PR, Espindola FS, Jardim AC, Vieira AA, Oliveira TL, Goulart LR, Sabino-Silva R. Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis. PLoS One. 2019 Sep 19;14(9):e0222575. doi: 10.1371/journal.pone.0222575. PMID: 31536570; PMCID: PMC6752759.

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1: Chen D, Yang M, Zheng N, Xie N, Liu D, Xie C, Yao D. A novel aptasensor for
electrochemical detection of ractopamine, clenbuterol, salbutamol,
phenylethanolamine and procaterol. Biosens Bioelectron. 2016 Jun 15;80:525-31.
doi: 10.1016/j.bios.2016.01.025. Epub 2016 Jan 11. PubMed PMID: 26890828.

2: Wang MY, Zhu W, Ma L, Ma JJ, Zhang DE, Tong ZW, Chen J. Enhanced simultaneous detection of ractopamine and salbutamol--Via electrochemical-facial deposition of MnO2 nanoflowers onto 3D RGO/Ni foam templates. Biosens Bioelectron. 2016 Apr15;78:259-66. doi: 10.1016/j.bios.2015.11.062. Epub 2015 Nov 22. PubMed PMID:26623510.

3: Flores P, Mendes AL, Neto AS. A randomized trial of nebulized 3% hypertonic
saline with salbutamol in the treatment of acute bronchiolitis in hospitalized
infants. Pediatr Pulmonol. 2016 Apr;51(4):418-25. doi: 10.1002/ppul.23306. Epub
2015 Sep 3. PubMed PMID: 26334188.

4: Rodríguez-Ramos F, Andrade-Moreno MÁ, Alfaro-Romero A, Balderas-López JL,
Navarrete A. Gnaphaliin A and gnaphaliin B synergize the relaxant effect of
salbutamol but not of ipratropium in guinea pig trachea. J Pharm Pharmacol. 2016
Apr 7. doi: 10.1111/jphp.12536. [Epub ahead of print] PubMed PMID: 27061296.

5: Andrzejowski P, Carroll W. Salbutamol in paediatrics: pharmacology,
prescribing and controversies. Arch Dis Child Educ Pract Ed. 2016 Apr 8. pii:
edpract-2014-307285. doi: 10.1136/archdischild-2014-307285. [Epub ahead of print] PubMed PMID: 27059284.