Quinethazone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318601

CAS#: 73-49-4

Description: Quinethazone is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.


Price and Availability

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Quinethazone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318601
Name: Quinethazone
CAS#: 73-49-4
Chemical Formula: C10H12ClN3O3S
Exact Mass: 289.02879
Molecular Weight: 289.74
Elemental Analysis: C, 41.45; H, 4.17; Cl, 12.24; N, 14.50; O, 16.57; S, 11.07


Synonym: Quinethazone; Chinethazonum; Quinethazon; Quinethazonum; Aquamox; Hydromox; quinethazone, (+)-isomer; quinethazone, (+-)-isomer; quinethazone, (-)-isomer;

IUPAC/Chemical Name: 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide

SMILES Code: CCC1NC2=CC(=C(C=C2C(=O)N1)S(=O)(=O)N)Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Olesen KH, Sigurd B. The supra-additive natriuretic effect addition of
quinethazone or bendroflumethiazide during long-term treatment with furosemide
and spironolactone. Permutation trial tests in patients with congestive heart
failure. Acta Med Scand. 1971 Sep;190(3):233-40. PubMed PMID: 4941227.

2: Olesen KH, Dupont B, Flensted-Jensen E. The combined diuretic action of
quinethazone and furosemide in congestive heart failure. A permutation trial
test. Acta Med Scand. 1970 Jan-Feb;187(1-2):33-40. PubMed PMID: 4912468.

3: Trifunović S, Stamenković Z. [The use of quinethazone in the treatment of
cardiac edema]. Med Glas. 1966 Jul;20(7):246-8. Serbian. PubMed PMID: 5986856.

4: Merker W, Bauer HR. [Quinethazone and acetazolamide in edematous diseases].
Med Klin. 1966 May 13;61(19):764-8. German. PubMed PMID: 5988324.

5: Angelopoulos B, Vlassopoulos C, Kalos A. Experimental investigation and
observations on the diuretic action of quinethazone. Med Pharmacol Exp Int J Exp
Med. 1966;14(6):528-36. PubMed PMID: 6012607.

6: Naik BK, Rao PS, Saboo RM, Parlay K. Clinical trial of Quinethazone--Reserpine
(diuretic cum antihypertensive--drug). J Assoc Physicians India. 1965
Aug;13(8):637-41. PubMed PMID: 5825030.

7: Baur M. [Pharmacologic-clinical tests of new diuretics. 1. Quinethazone].
Arzneimittelforschung. 1965 Jul;15(7):806-12. German. PubMed PMID: 5324710.

8: Diamond S, Feldman E. [Treatment of essential hypertension with quinethazone
and reserpine]. Hospital (Rio J). 1965 Jul;68(1):83-8. Portuguese. PubMed PMID:
5322319.

9: Kozma JJ. [Use of quinethazone combined with reserpine in hypertension]. Folha
Med. 1965 Jun;50(6):413-7. Portuguese. PubMed PMID: 5850507.

10: Rognoni M, Guevara F, Brown A. [Quinethazone (Aquamox Lederle)]. Arch Med
Panamenos. 1965 Apr;14(1):17-22. Spanish. PubMed PMID: 5839433.

11: KOZMA JJ. CLINICAL EVALUATION OF QUINETHAZONE-RESERPINE COMBINATION IN
HYPERTENSION. Curr Ther Res Clin Exp. 1964 Nov;6:664-9. PubMed PMID: 14240756.

12: RIOSMOZO M. [TREATMENT OF ARTERIAL HYPERTENSION WITH QUINETHAZONE AND
QUINETHAZONE-RESERPINE]. Hisp Med. 1964 Aug;21:465-83. Spanish. PubMed PMID:
14202221.

13: KLEINSCHMIDT A, LUDWIG H. [INCREASED NATRIURESIS BY MEANS OF A DIURETIC
COMBINATION (QUINETHAZONE-ACETAZOLAMIDE)]. Med Klin. 1964 Jun 26;59:1063-8.
German. PubMed PMID: 14243296.

14: HUTCHEON DE, LEONARD GB, LONIEWSKI AE. BIOASSAY OF DIURETICS IN CONGESTIVE
HEART FAILURE. A COMPARISON OF QUINETHAZONE WITH HYDROCHLOROTHIAZIDE. J New
Drugs. 1964 May-Jun;4(3):148-53. PubMed PMID: 14185005.

15: HUTCHISON JC, ROEDIGER PM, WERBLIN M. CHOLESTATIC JAUNDICE FOLLOWING
ADMINISTRATION OF QUINETHAZONE. Curr Ther Res Clin Exp. 1964 Mar;6:199-201.
PubMed PMID: 14131421.

16: DIAMOND S, FELDMAN E. TREATMENT OF ESSENTIAL HYPERTENSION WITH QUINETHAZONE
PLUS RESERPINE. Curr Ther Res Clin Exp. 1964 Jan;6:62-6. PubMed PMID: 14105061.

17: FREED SC. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proc Soc Exp
Biol Med. 1963 Nov;114:421-2. PubMed PMID: 14101206.

18: HALLESY DW, BENITZ KF. [TOXICITY TESTS OF QUINETHAZONE].
Arzneimittelforschung. 1963 Aug;13:665-73. German. PubMed PMID: 14085919.

19: SHIOJI T, FURUYAMA T, ABE S, SUZUKI C, MAKABE K, RIKIMARU S. [STUDIES ON
DIURETIC AND ANTIHYPERTENSIVE EFFECTS OF QUINETHAZONE]. Naika Hokan. 1963
Aug;10:397-405. Japanese. PubMed PMID: 14057126.

20: DATEY KK, PANDYA VN. QUINETHAZONE AS A DIURETIC AGENT. J Postgrad Med. 1963
Jul;9:99-105. PubMed PMID: 14066683.