YM-90709
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MedKoo CAT#: 407312

CAS#: 163769-88-8

Description: YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 3950
Size
Price

50mg
USD 450
500mg
USD 1950
5g
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YM-90709, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407312
Name: YM-90709
CAS#: 163769-88-8
Chemical Formula: C22H21N3O2
Exact Mass: 359.1634
Molecular Weight: 359.429
Elemental Analysis: C, 73.52; H, 5.89; N, 11.69; O, 8.90


Synonym: YM-90709; YM 90709; YM90709.

IUPAC/Chemical Name: 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline

InChi Key: HIXSPVQXXDULHS-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3

SMILES Code: CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Morokata T, Suzuki K, Ida K, Yamada T. Effect of a novel interleukin-5
receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into
the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5. Epub 2004 Nov 28.
PubMed PMID: 15790522.

2: Morokata T, Suzuki K, Ida K, Tsuchiyama H, Ishikawa J, Yamada T. Effect of a
novel interleukin-5 receptor antagonist, YM-90709
(2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline),
on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004
Jul;4(7):873-83. PubMed PMID: 15182727.

3: Morokata T, Ida K, Yamada T. Characterization of YM-90709 as a novel
antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.
Int Immunopharmacol. 2002 Nov;2(12):1693-702. PubMed PMID: 12469943.