Naftifine HCl
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MedKoo CAT#: 318299

CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).

Description: Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.


Price and Availability

Size
Price

100mg
USD 150
1g
USD 550
10g
USD 2450
Size
Price

200mg
USD 250
2g
USD 850
20g
Ask price
Size
Price

500mg
USD 350
5g
USD 1450

Naftifine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318299
Name: Naftifine HCl
CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).
Chemical Formula: C21H22ClN
Exact Mass:
Molecular Weight: 323.864
Elemental Analysis: C, 77.88; H, 6.85; Cl, 10.95; N, 4.32


Synonym: AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin

IUPAC/Chemical Name: (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride

SMILES Code: CN(CC1=C2C=CC=CC2=CC=C1)C/C=C/C3=CC=CC=C3.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Del Rosso JQ, Kircik LH. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. J Drugs Dermatol. 2013 Nov;12(11 Suppl):s165-71. Review. PubMed PMID: 24196340.

2: Gupta AK, Ryder JE, Cooper EA. Naftifine: a review. J Cutan Med Surg. 2008 Mar-Apr;12(2):51-8. Review. PubMed PMID: 18346400.

3: Mühlbacher JM. Naftifine: a topical allylamine antifungal agent. Clin Dermatol. 1991 Oct-Dec;9(4):479-85. Review. PubMed PMID: 1822408.

4: Monk JP, Brogden RN. Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1991 Oct;42(4):659-72. Review. PubMed PMID: 1723367.