Suprofen | CAS#40828-46-4

Suprofen
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318783

CAS#: 40828-46-4

Description: Suprofen is a non-steroidal anti-inflammatory drug.

Chemical Structure

Suprofen

CAS# 40828-46-4

Instruction

Theoretical Analysis

MedKoo Cat#: 318783
Name: Suprofen
CAS#: 40828-46-4
Chemical Formula: C14H12O3S
Exact Mass: 260.05
Molecular Weight: 260.307
Elemental Analysis: C, 64.60; H, 4.65; O, 18.44; S, 12.32

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 190
25mg	USD 400
50mg	USD 750
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: R-25061; R25061; R 25061; Suprofen; Suprofenum; Profenal

IUPAC/Chemical Name: 2-(4-(thiophene-2-carbonyl)phenyl)propanoic acid

InChi Key: MDKGKXOCJGEUJW-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 260.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Musa KA, Eriksson LA. Photodegradation mechanism of nonsteroidal anti-inflammatory drugs containing thiophene moieties: suprofen and tiaprofenic acid. J Phys Chem B. 2009 Aug 13;113(32):11306-13. doi: 10.1021/jp904171p. PubMed PMID: 19719267.

2: Hutzler JM, Balogh LM, Zientek M, Kumar V, Tracy TS. Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection. Drug Metab Dispos. 2009 Jan;37(1):59-65. doi: 10.1124/dmd.108.023358. Epub 2008 Oct 6. PubMed PMID: 18838506; PubMed Central PMCID: PMC2610245.

3: Dawood MY, Khan-Dawood FS. Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea. Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):146-53. Epub 2006 Dec 8. PubMed PMID: 17259081.

4: Wang LW, Cheng YC, Tsai SW. Process modeling of the lipase-catalyzed dynamic kinetic resolution of (R, S)-suprofen 2,2,2-trifluoroethyl thioester in a hollow-fiber membrane. Bioprocess Biosyst Eng. 2004 Dec;27(1):39-49. Epub 2004 Nov 18. PubMed PMID: 15645310.

5: Cirli OO, Hasirci V. UV-induced drug release from photoactive REV sensitized by suprofen. J Control Release. 2004 Apr 16;96(1):85-96. PubMed PMID: 15063031.

6: Shrivastava SK, Jain DK, Trivedi P. Dextrans--potential polymeric drug carriers for suprofen. Pharmazie. 2003 Nov;58(11):804-6. PubMed PMID: 14664336.

7: O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen. Drug Metab Dispos. 2003 Nov;31(11):1369-77. PubMed PMID: 14570769.

8: Moison RM, Rijnkels JM, Podda E, Righele F, Tomasello F, Caffieri S, Beijersbergen van Henegouwen GM. Topically applied vitamin C and cysteine derivatives protect against UVA-induced photodegradation of suprofen in ex vivo pigskin. Photochem Photobiol. 2003 Apr;77(4):343-8. PubMed PMID: 12733644.

9: Sugiura M, Hayakawa R, Xie Z, Sugiura K, Hiramoto K, Shamoto M. Experimental study on phototoxicity and the photosensitization potential of ketoprofen, suprofen, tiaprofenic acid and benzophenone and the photocross-reactivity in guinea pigs. Photodermatol Photoimmunol Photomed. 2002 Apr;18(2):82-9. PubMed PMID: 12147041.

10: Imamura Y, Higuchi T, Otagiri M. Protective effects of suprofen and its methyl ester against inactivation of rabbit kidney carbonyl reductase by phenylglyoxal. J Enzyme Inhib. 2001 Nov;16(5):451-5. PubMed PMID: 11916151.

11: Moser J, Hye A, Lovell WW, Earl LK, Castell JV, Miranda MA. Mechanisms of drug photobinding to proteins: photobinding of suprofen to human serum albumin. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):333-7. PubMed PMID: 11566558.

12: Castro EF, Soraci AL, Franci R, Fogel FA, Tapia MO. Disposition of suprofen enantiomers in the cat. Vet J. 2001 Jul;162(1):38-43. PubMed PMID: 11409928.

13: Sarabia Z, Hernández D, Castell JV, van Henegouwen GM. Photoreactivity of tiaprofenic acid and suprofen using pig skin as an ex vivo model. J Photochem Photobiol B. 2000 Oct;58(1):32-6. PubMed PMID: 11195850.

14: Starrs SM, Davies RJ. Sequence specificity of alkali-labile DNA damage photosensitized by suprofen. Photochem Photobiol. 2000 Sep;72(3):291-7. PubMed PMID: 10989597.

15: Lin CN, Tsai SW. Dynamic kinetic resolution of suprofen thioester via coupled trioctylamine and lipase catalysis. Biotechnol Bioeng. 2000 Jul 5;69(1):31-8. PubMed PMID: 10820328.

16: Chiou YJ, Tomer KB, Smith PC. Effect of nonenzymatic glycation of albumin and superoxide dismutase by glucuronic acid and suprofen acyl glucuronide on their functions in vitro. Chem Biol Interact. 1999 Jul 1;121(2):141-59. PubMed PMID: 10418961.

17: Castell JV, Hernández D, Gómez-Lechón MJ, Lahoz A, Miranda MA, Morera IM, Pérez-Prieto J, Sarabia Z. Photobinding of tiaprofenic acid and suprofen to proteins and cells: a combined study using radiolabeling, antibodies and laser flash photolysis of model bichromophores. Photochem Photobiol. 1998 Nov;68(5):660-5. PubMed PMID: 9825695.

18: Sortino S, De Guidi G, Marconi G, Monti S. Triplet photochemistry of suprofen in aqueous environment and in the beta-cyclodextrin inclusion complex. Photochem Photobiol. 1998 Jun;67(6):603-11. PubMed PMID: 9687264.

19: Giammona G, Pitarresi G, Tomarchio V, De Guidi G, Giuffrida S. Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour. J Control Release. 1998 Feb 12;51(2-3):249-57. PubMed PMID: 9685923.

20: Ward DA. Comparative efficacy of topically applied flurbiprofen, diclofenac, tolmetin, and suprofen for the treatment of experimentally induced blood-aqueous barrier disruption in dogs. Am J Vet Res. 1996 Jun;57(6):875-8. PubMed PMID: 8725816.

Your view history

Suprofen featured