LCB 03-0110 dihydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 523102

CAS#: 1962928-28-4

Description: LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC50 = 1.3 nM). It is also a potent inhibitor of BTK and Syk, discoidin domain receptor 2 (DDR2) family tyrosine kinases. The mechanism of action is it suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. LCB 03-0110 dihydrochloride also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Chemical Structure

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LCB 03-0110 dihydrochloride
CAS# 1962928-28-4
Instruction

Theoretical Analysis

MedKoo Cat#: 523102
Name: LCB 03-0110 dihydrochloride
CAS#: 1962928-28-4
Chemical Formula: C24H25Cl2N3O2S
Exact Mass: 489.10
Molecular Weight: 490.440
Elemental Analysis: C, 58.78; H, 5.14; Cl, 14.46; N, 8.57; O, 6.52; S, 6.54

Price and Availability

Size Price Availability Quantity
10mg USD 485 2 Weeks
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Synonym: LCB 03-0110 dihydrochloride; LCB 03-0110 HCl

IUPAC/Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride

InChi Key: OEWGAUGZPPUIPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H23N3O2S.2ClH/c28-20-6-2-5-19(14-20)26-21-7-8-25-22-15-23(30-24(21)22)18-4-1-3-17(13-18)16-27-9-11-29-12-10-27;;/h1-8,13-15,28H,9-12,16H2,(H,25,26);2*1H

SMILES Code: OC1=CC=CC(NC2=C3C(C=C(C4=CC=CC(CN5CCOCC5)=C4)S3)=NC=C2)=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 490.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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