Nabumetone
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MedKoo CAT#: 318296

CAS#: 42924-53-8

Description: Nabumetone is a non-steroidal anti-inflammatory drug (NSAID), the only 1-naphthaleneacetic acid derivative. It is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). The active metabolite of nabumetone is felt to be the compound primarily responsible for therapeutic effect. Comparatively, the parent drug is a poor inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin.


Price and Availability

Size
Price

10mg
USD 180
100mg
USD 350
1g
USD 650
10g
USD 1050
100g
USD 1650
Size
Price

25mg
USD 200
200mg
USD 450
2g
USD 750
20g
USD 1350
200g
Ask price
Size
Price

50mg
USD 250
500mg
USD 550
5g
USD 850
50g
USD 1450
500g
Ask price

Nabumetone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318296
Name: Nabumetone
CAS#: 42924-53-8
Chemical Formula: C15H16O2
Exact Mass: 228.115
Molecular Weight: 228.2863
Elemental Analysis: C, 78.92; H, 7.06; O, 14.02


Synonym: Nabumetone, Relafen, Relifex, Gambaran, Arthraxan, BRL 14777

IUPAC/Chemical Name: 4-(6-methoxynaphthalen-2-yl)butan-2-one

InChi Key: BLXXJMDCKKHMKV-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

SMILES Code: CC(CCC1=CC=C2C=C(OC)C=CC2=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Moore RA, Derry S, Moore M, McQuay HJ. Single dose oral nabumetone for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007548. doi: 10.1002/14651858.CD007548.pub2. Review. PubMed PMID: 19821428; PubMed Central PMCID: PMC4170900.

2: Starek M, Krzek J. A review of analytical techniques for determination of oxicams, nimesulide and nabumetone. Talanta. 2009 Jan 15;77(3):925-42. doi: 10.1016/j.talanta.2008.09.022. Epub 2008 Sep 24. Review. PubMed PMID: 19064072.

3: Bannwarth B. Safety of the nonselective NSAID nabumetone : focus on gastrointestinal tolerability. Drug Saf. 2008;31(6):485-503. Review. PubMed PMID: 18484783.

4: Hedner T, Samulesson O, Währborg P, Wadenvik H, Ung KA, Ekbom A. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. Drugs. 2004;64(20):2315-43; discussion 2344-5. Review. PubMed PMID: 15456329.

5: Davies NM, McLachlan AJ. [Properties and features of nabumetone]. Drugs. 2000;59 Spec No 1:25-33. Review. French. PubMed PMID: 10841070.

6: Davies NM. Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition? Clin Pharmacokinet. 1997 Dec;33(6):404-16. Review. PubMed PMID: 9435990.

7: Hilleman DE, Mohiuddin SM, Lucas BD Jr. Nonsteroidal antiinflammatory drug use in patients receiving warfarin: emphasis on nabumetone. Am J Med. 1993 Aug 9;95(2A):30S-34S. Review. PubMed PMID: 8357000.

8: Roth SH. Upper gastrointestinal safety with nabumetone. J Rheumatol Suppl. 1992 Nov;36:74-9. Review. PubMed PMID: 1474539.

9: Bernhard GC. Worldwide safety experience with nabumetone. J Rheumatol Suppl. 1992 Nov;36:48-57. Review. PubMed PMID: 1474535.

10: Hyneck ML. An overview of the clinical pharmacokinetics of nabumetone. J Rheumatol Suppl. 1992 Nov;36:20-4. Review. PubMed PMID: 1474531.

11: Blower PR. The unique pharmacologic profile of nabumetone. J Rheumatol Suppl. 1992 Nov;36:13-9. Review. PubMed PMID: 1474529.

12: Nabumetone (Relifex)--another NSAID. Drug Ther Bull. 1988 May 31;26(11):41-3. Review. Erratum in: Drug Ther Bull 1988 Aug 22;26(17):68. PubMed PMID: 3289871.

13: Friedel HA, Todd PA. Nabumetone. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases. Drugs. 1988 May;35(5):504-24. Review. PubMed PMID: 3293969.

14: Roth SH. [Rationale for using nabumetone and clinical experience]. Drugs. 2000;59 Spec No 1:35-41. Review. French. PubMed PMID: 10841071.

15: Nasonov EL, Nasonova SV. [Nabumetone, a new nonsteroidal antiinflammatory agent: clinical prospects]. Klin Med (Mosk). 1996;74(8):13-6. Review. Russian. PubMed PMID: 9036198.

16: Simón M, Sádaba B, Honorato J. [Nabumetone]. Rev Med Univ Navarra. 1995 Jul-Sep;39(3):164-72. Review. Spanish. PubMed PMID: 8552919.

17: Helfgott SM. Nabumetone: a clinical appraisal. Semin Arthritis Rheum. 1994 Apr;23(5):341-6. Review. PubMed PMID: 8036523.

18: Dahl SL. Nabumetone: a "nonacidic" nonsteroidal antiinflammatory drug. Ann Pharmacother. 1993 Apr;27(4):456-63. Review. PubMed PMID: 8477124.

19: Aronoff GR. Therapeutic implications associated with renal studies of nabumetone. J Rheumatol Suppl. 1992 Nov;36:25-31. Review. PubMed PMID: 1474532.

20: Roth SH. Nabumetone: a new NSAID for rheumatoid arthritis and osteoarthritis. Orthop Rev. 1992 Feb;21(2):223-7. Review. PubMed PMID: 1538889.