L67
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MedKoo CAT#: 407299

CAS#: 325970-71-6

Description: L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I and III with IC₅₀ values of 10 μM and 10 μM.). L67 significantly increased the cytotoxicity of DNA-damaging.


Price and Availability

Size
Price

10mg
USD 70
100mg
USD 250
1g
USD 1450
Size
Price

25mg
USD 120
200mg
USD 450
2g
USD 2450
Size
Price

50mg
USD 150
500mg
USD 850
5g
Ask price

L67, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407299
Name: L67
CAS#: 325970-71-6
Chemical Formula: C16H14Br2N4O4
Exact Mass: 483.9382
Molecular Weight: 486.12
Elemental Analysis: C, 39.53; H, 2.90; Br, 32.87; N, 11.53; O, 13.16


Synonym: L67; L-67; L 67.

IUPAC/Chemical Name: E-2-((3,5-Dibromo-4-methylphenyl)amino)-N’-(2-hydroxy-5-nitrobenzylidene)acetohydrazide

InChi Key: KFEPVFJQVOMODD-IFRROFPPSA-N

InChi Code: InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+

SMILES Code: O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)CNC2=CC(Br)=C(C)C(Br)=C2


Technical Data

Appearance:
Light yellow to yellow solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell
AD Jr, Tomkinson AE. Rational design of human DNA ligase inhibitors that target
cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. doi:
10.1158/0008-5472.CAN-07-6636. PubMed PMID: 18451142; PubMed Central PMCID:
PMC2734474.