Mesoridazine Besylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318193

CAS#: 32672-69-8 (besylate)

Description: Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent.

Chemical Structure

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Mesoridazine Besylate
CAS# 32672-69-8 (besylate)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 318193
Name: Mesoridazine Besylate
CAS#: 32672-69-8 (besylate)
Chemical Formula: C27H32N2O4S3
Exact Mass: 0.00
Molecular Weight: 544.743
Elemental Analysis: C, 59.53; H, 5.92; N, 5.14; O, 11.75; S, 17.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 5588-33-0 (free base)   32672-69-8 (besylate)   59884-26-3 (HCl)    

Synonym: Mesoridazine Besylate; Mesoridazine benzenesulfonate; NC 123; CHEBI:6781; C21H26N2OS2.C6H6O3S; PL054141; SAM001247051; SMR000449304; D00795;

IUPAC/Chemical Name: 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine benzenesulfonate

InChi Key: CRJHBCPQHRVYBS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H26N2OS2.C6H6O3S/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23;7-10(8,9)6-4-2-1-3-5-6/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1-5H,(H,7,8,9)

SMILES Code: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent.
In vitro activity: Mesoridazine blocked HERG currents in a concentration-dependent manner (IC50 550 nM at 0 mV); block increased significantly over the voltage range where HERG activates and saturated at voltages eliciting maximal HERG channel activation. Reference: J Mol Cell Cardiol. 2004 Jan;36(1):151-60. https://pubmed.ncbi.nlm.nih.gov/14734057/
In vivo activity: Using a subcutaneous injection model in rats, this study tested the cutaneous analgesic effects of six phenothiazine-type antipsychotics (mesoridazine, promazine, chlorpromazine, fluphenazine, perphenazine and triflupromazine) at a dose of 0.6 mumol, and compared them with those of bupivacaine and lidocaine. Mesoridazine had a longer duration of action than bupivacaine (p<0.001). In terms of ED(50) values, mesoridazine was more potent and longer-acting than bupivacaine and lidocaine (p<0.01 for each comparison). Reference: Acta Anaesthesiol Taiwan. 2010 Mar;48(1):3-7. https://pubmed.ncbi.nlm.nih.gov/20434106/

Preparing Stock Solutions

The following data is based on the product molecular weight 544.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Su Z, Martin R, Cox BF, Gintant G. Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel. J Mol Cell Cardiol. 2004 Jan;36(1):151-60. doi: 10.1016/j.yjmcc.2003.10.017. PMID: 14734057. 2. Liu KS, Chen YW, Aljuffali IA, Chang CW, Wang JJ, Fang JY. Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: The skin absorption assessment. Eur J Pharm Biopharm. 2016 Aug;105:59-68. doi: 10.1016/j.ejpb.2016.05.025. Epub 2016 May 31. PMID: 27260201. 3. Chen YW, Chu CC, Chu KS, Shieh JP, Chien CC, Wang JJ, Kao CH. Phenothiazine-type antipsychotics elicit cutaneous analgesia in rats. Acta Anaesthesiol Taiwan. 2010 Mar;48(1):3-7. doi: 10.1016/S1875-4597(10)60002-1. PMID: 20434106.
In vitro protocol: 1. Su Z, Martin R, Cox BF, Gintant G. Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel. J Mol Cell Cardiol. 2004 Jan;36(1):151-60. doi: 10.1016/j.yjmcc.2003.10.017. PMID: 14734057.
In vivo protocol: 1. Liu KS, Chen YW, Aljuffali IA, Chang CW, Wang JJ, Fang JY. Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: The skin absorption assessment. Eur J Pharm Biopharm. 2016 Aug;105:59-68. doi: 10.1016/j.ejpb.2016.05.025. Epub 2016 May 31. PMID: 27260201. 2. Chen YW, Chu CC, Chu KS, Shieh JP, Chien CC, Wang JJ, Kao CH. Phenothiazine-type antipsychotics elicit cutaneous analgesia in rats. Acta Anaesthesiol Taiwan. 2010 Mar;48(1):3-7. doi: 10.1016/S1875-4597(10)60002-1. PMID: 20434106.

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1: Morrow RJ, Millership JS, Collier PS. Diastereotopic analysis of mesoridazine
besylate (Serentil). Chirality. 2004 Oct;16(8):534-40. PubMed PMID: 15290689.


2: Shader RI. Sexual dysfunction associated with mesoridazine besylate
(serentil). Psychopharmacologia. 1972;27(3):293-4. PubMed PMID: 4674517.


3: Salih IS, Thanacoody RH, McKay GA, Thomas SH. Comparison of the effects of
thioridazine and mesoridazine on the QT interval in healthy adults after single
oral doses. Clin Pharmacol Ther. 2007 Nov;82(5):548-54. Epub 2007 Apr 4. PubMed
PMID: 17410120.


4: Aguilar SJ. An open study of mesoridazine (Serentil) in chronic
schizophrenics. Dis Nerv Syst. 1975 Sep;36(9):484-9. PubMed PMID: 1175465.


5: Niemann JT, Stapczynski JS, Rothstein RJ, Laks MM. Cardiac conduction and
rhythm disturbances following suicidal ingestion of mesoridazine. Ann Emerg Med.
1981 Nov;10(11):585-8. PubMed PMID: 7316263.


6: Walker ST. Liquid chromatographic determination of organic nitrogenous bases
in dosage forms: a progress report. J Assoc Off Anal Chem. 1985
May-Jun;68(3):539-42. PubMed PMID: 4019383.


7: Theesen KA, Wilson JE, Newton DW, Ueda CT. Compatibility of lithium citrate
syrup with 10 neuroleptic solutions. Am J Hosp Pharm. 1981 Nov;38(11):1750-3.
PubMed PMID: 6118064.