Naratriptan free base
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MedKoo CAT#: 318351

CAS#: 121679-13-8 (free base)

Description: Naratriptan is a selective 5-HT1 receptor subtype agonist for the treatment of migraine headache. Naratriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Migraines are likely due to local cranial vasodilatation and/or to the release of sensory neuropeptides (including substance P and calcitonin gene-related peptide) through nerve endings in the trigeminal system. The therapeutic activity of AMERGE for the treatment of migraine headache is thought to be due to the agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels (including the arterio-venous anastomoses) and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.


Chemical Structure

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Naratriptan free base
CAS# 121679-13-8 (free base)

Theoretical Analysis

MedKoo Cat#: 318351
Name: Naratriptan free base
CAS#: 121679-13-8 (free base)
Chemical Formula: C17H25N3O2S
Exact Mass: 335.17
Molecular Weight: 335.466
Elemental Analysis: C, 60.87; H, 7.51; N, 12.53; O, 9.54; S, 9.56

Price and Availability

Size Price Availability Quantity
10mg USD 285 2 Weeks
50mg USD 750 2 Weeks
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Related CAS #: 121679-13-8 (free base)   143388-64-1 (HCl),  

Synonym: Naratriptan free base; Amerge; Colatan; GR 85548; GR-85548; GR85548;

IUPAC/Chemical Name: 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)-

InChi Key: AMKVXSZCKVJAGH-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3

SMILES Code: O=S(CCC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)(NC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: 1. Pauwels PJ, Colpaert FC. Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935. Eur J Pharmacol. 1996 Apr 4;300(1-2):141-5. doi: 10.1016/0014-2999(96)00011-8. PMID: 8741180. 2. Park J, Moon H, Akerman S, Holland PR, Lasalandra MP, Andreou AP, Ferrari MD, van den Maagdenberg AM, Goadsby PJ. Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study. Neurobiol Dis. 2014 Apr;64:1-7. doi: 10.1016/j.nbd.2013.12.004. Epub 2013 Dec 17. PMID: 24355314. 3. Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G. Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med. 2012 Oct;18(10):1531-8. doi: 10.1038/nm.2932. Epub 2012 Sep 30. PMID: 23023499.
In vitro activity: 1. Pauwels PJ, Colpaert FC. Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935. Eur J Pharmacol. 1996 Apr 4;300(1-2):141-5. doi: 10.1016/0014-2999(96)00011-8. PMID: 8741180.
In vivo activity: 1. Park J, Moon H, Akerman S, Holland PR, Lasalandra MP, Andreou AP, Ferrari MD, van den Maagdenberg AM, Goadsby PJ. Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study. Neurobiol Dis. 2014 Apr;64:1-7. doi: 10.1016/j.nbd.2013.12.004. Epub 2013 Dec 17. PMID: 24355314. 2. Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G. Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med. 2012 Oct;18(10):1531-8. doi: 10.1038/nm.2932. Epub 2012 Sep 30. PMID: 23023499.

Preparing Stock Solutions

The following data is based on the product molecular weight 335.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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