ACY-738
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MedKoo CAT#: 407295

CAS#: 1375465-91-0

Description: ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-738 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors in novel, but not familiar environments.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2150
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 3650
Size
Price

50mg
USD 450
500mg
USD 1450
5g
USD 4950

ACY-738, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 2g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407295
Name: ACY-738
CAS#: 1375465-91-0
Chemical Formula: C14H14N4O2
Exact Mass: 270.1117
Molecular Weight: 270.292
Elemental Analysis: C, 62.21; H, 5.22; N, 20.73; O, 11.84


Synonym: ACY-738; ACY 738; ACY738.

IUPAC/Chemical Name: N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide

InChi Key: LIIWIMDSZVNYHY-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)

SMILES Code: O=C(C1=CN=C(NC2(C3=CC=CC=C3)CC2)N=C1)NO


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Regna NL, Vieson MD, Luo XM, Chafin CB, Puthiyaveetil AG, Hammond SE, Caudell DL, Jarpe MB, Reilly CM. Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice. Clin Immunol. 2016 Jan;162:58-73. doi: 10.1016/j.clim.2015.11.007. Epub 2015 Nov 22. PubMed PMID: 26604012.

2: Regna NL, Vieson MD, Gojmerac AM, Luo XM, Caudell DL, Reilly CM. HDAC expression and activity is upregulated in diseased lupus-prone mice. Int Immunopharmacol. 2015 Dec;29(2):494-503. doi: 10.1016/j.intimp.2015.10.006. Epub 2015 Oct 21. PubMed PMID: 26471208; PubMed Central PMCID: PMC4666739.

3: Jochems J, Teegarden SL, Chen Y, Boulden J, Challis C, Ben-Dor GA, Kim SF, Berton O. Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics. Biol Psychiatry. 2015 Feb 15;77(4):345-55. doi: 10.1016/j.biopsych.2014.07.036. Epub 2014 Aug 28. PubMed PMID: 25442004; PubMed Central PMCID: PMC4297530.

4: Cook C, Carlomagno Y, Gendron TF, Dunmore J, Scheffel K, Stetler C, Davis M, Dickson D, Jarpe M, DeTure M, Petrucelli L. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum Mol Genet. 2014 Jan 1;23(1):104-16. doi: 10.1093/hmg/ddt402. Epub 2013 Aug 19. PubMed PMID: 23962722; PubMed Central PMCID: PMC3857946.

5: Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH, Jones S, Berton O. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014 Jan;39(2):389-400. doi: 10.1038/npp.2013.207. Epub 2013 Aug 19. PubMed PMID: 23954848; PubMed Central PMCID: PMC3870780.

6: Mithraprabhu S, Khong T, Jones SS, Spencer A. Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62. doi: 10.1111/bjh.12388. Epub 2013 May 21. PubMed PMID: 23692150.