Maprotiline Hydrochlorine
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MedKoo CAT#: 318172

CAS#: 10347-81-6

Description: Maprotiline Hydrochloride is the hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors.


Price and Availability

Size
Price

200mg
USD 150
2g
USD 750
Size
Price

500mg
USD 250
Size
Price

1g
USD 450

Maprotiline Hydrochlorine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318172
Name: Maprotiline Hydrochlorine
CAS#: 10347-81-6
Chemical Formula: C20H24ClN
Exact Mass:
Molecular Weight: 313.86
Elemental Analysis: C, 76.53; H, 7.71; Cl, 11.30; N, 4.46


Related CAS #: 10347-81-6 (HCl)   10262-69-8 (free)  

Synonym: Maprotiline Hydrochlorine;Maprotiline Hcl; Psymion; Ludiomil; Maprotilline HCl; Teva Brand of Maprotiline Hydrochloride;

IUPAC/Chemical Name: 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

InChi Key: NZDMFGKECODQRY-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H

SMILES Code: CNCCCC1(CC2)C3=CC=CC=C3C2C4=C1C=CC=C4.Cl


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ozkul A, Oztunç A. Determination of maprotiline hydrochloride in tablets by
ion-pair extraction using bromthymol blue. Pharmazie. 2000 Apr;55(4):321-2.
PubMed PMID: 10798251.

2: Ersoy L, Alpertunga B. Spectrophotometric determination of maprotiline
hydrochloride. Analyst. 1988 Nov;113(11):1745-6. PubMed PMID: 3232826.

3: North DS, Retzinger T, Thompson JD. Seizures and delirium associated with
overdosage of maprotiline hydrochloride. Clin Pharm. 1983 Jul-Aug;2(4):370-3.
PubMed PMID: 6883966.

4: Schwartz L, Swaminathan S. Maprotiline hydrochloride and convulsions: a case
report. Am J Psychiatry. 1982 Feb;139(2):244-5. PubMed PMID: 6798885.

5: Wells BG, Gelenberg AJ. Chemistry, pharmacology, pharmacokinetics, adverse
effects, and efficacy of the antidepressant maprotiline hydrochloride.
Pharmacotherapy. 1981 Sep-Oct;1(2):121-39. PubMed PMID: 6765485.

6: Trimble M. Maprotiline hydrochloride and grand-mal seizures. Br Med J. 1978
Nov 18;2(6149):1430. PubMed PMID: 102405; PubMed Central PMCID: PMC1608645.

7: Hall MJ, Russell RI. Maprotiline hydrochloride and grand-mal seizures. Br Med
J. 1978 Sep 30;2(6142):961. PubMed PMID: 101269; PubMed Central PMCID:
PMC1608082.

8: Saiz I, González Martínez JL, Velasco-Martín A. [Effect of maprotiline
hydrochloride on oxygen and glucose consumption and oxidative phosphorylation of
rat brain in vitro]. Arch Farmacol Toxicol. 1978 Apr;4(1):37-8. Spanish. PubMed
PMID: 697400.

9: Celentano AM, González Cappa SM. [Chagas' disease and blood transfusion:
trypanocidal activity of maprotiline hydrochloride and gentian violet]. Medicina
(B Aires). 1988;48(3):265-8. Spanish. PubMed PMID: 3150028.

10: Atri PB, Julius DA. Maprotiline hydrochloride associated with a clinical
state of catatonic stupor and epileptic encephalogram. J Clin Psychopharmacol.
1984 Aug;4(4):207-9. PubMed PMID: 6470193.

11: Multicenter evaluation of maprotiline hydrochloride for treatment of
depression. Clin Ther. 1984;6(2):155-62. PubMed PMID: 6367987.

12: Treatment of depression with maprotiline hydrochloride: multicenter
evaluation of efficacy and tolerability. Clin Ther. 1983;5(4):377-84. PubMed
PMID: 6347381.

13: Marks P, Anderson J, Vincent R, Hutchinson JT, Rees HM. Epileptiform seizures
with maprotiline hydrochloride. Postgrad Med J. 1979 Oct;55(648):742. PubMed
PMID: 537962; PubMed Central PMCID: PMC2425754.

14: Burley D, Jukes A, Steen J. Maprotiline hydrochloride and grand-mal seizures.
Br Med J. 1978 Oct 28;2(6146):1230. PubMed PMID: 102397; PubMed Central PMCID:
PMC1608336.

15: Shepherd GA, Kerr F. Maprotiline hydrochloride and grand-mal seizures. Br Med
J. 1978 Jun 10;1(6126):1523. PubMed PMID: 418842; PubMed Central PMCID:
PMC1605044.

16: Gónzález de Zárate JL, Martínez-Acitores IS, Velasco-Martín A. Effect of
maprotiline hydrochloride on oxygen and glucose uptake and on oxidative
phosphorylation of rat brain in vitro. Farmaco Prat. 1978;33(4):183-6. PubMed
PMID: 729774.

17: Park J, Proudfoot AT. Acute poisoning with maprotiline hydrochloride. Br Med
J. 1977 Jun 18;1(6076):1573. PubMed PMID: 871669; PubMed Central PMCID:
PMC1607357.