Homatropine Methylbromide
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317993

CAS#: 80-49-9

Description: Homatropine Methylbromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics. It is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.


Chemical Structure

img
Homatropine Methylbromide
CAS# 80-49-9

Theoretical Analysis

MedKoo Cat#: 317993
Name: Homatropine Methylbromide
CAS#: 80-49-9
Chemical Formula: C17H24BrNO3
Exact Mass: 0.00
Molecular Weight: 370.287
Elemental Analysis: C, 55.14; H, 6.53; Br, 21.58; N, 3.78; O, 12.96

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 450 2 Weeks
25g USD 850 2 Weeks
Bulk inquiry

Synonym: Homatropine Methylbromide; Omatropina metilbromuro; 8-Methylhomatropinium bromide; Homatropine methobromide; Homatropine methyl bromide; AC1L1MZP; Methylhomatropine;

IUPAC/Chemical Name: (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;bromide

InChi Key: FUFVKLQESJNNAN-UHFFFAOYSA-M

InChi Code: InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1

SMILES Code: C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 2.0 5.40
DMSO 41.7 112.53
Ethanol 74.0 199.84
PBS (pH 7.2) 10.0 27.01
Water 74.0 199.84

Preparing Stock Solutions

The following data is based on the product molecular weight 370.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Yang L, Xu Z, Dong R, Fan J, Du Y, Zhang Y, Wang X, Cheng X, Guo J. Is surgery
necessary for patients with hepatic angiomyolipoma? Retrospective analysis from
eight Chinese cases. J Gastroenterol Hepatol. 2013 Oct;28(10):1648-53. doi:
10.1111/jgh.12289. PubMed PMID: 23731017.


2: BATTERMAN RC, MOURATOFF GJ. Influence of morphine, codeine, meperidine,
ephedrine and homatropine methylbromide upon absorption of aspirin from the
gastro-intestinal tract of man. Curr Ther Res Clin Exp. 1961 May;3:193-200.
PubMed PMID: 13687794.


3: EDUARDO, BILLINGHURST GA. [Symptomatic treatment of Meniere's syndrome with
homatropine methylbromide]. Sem Med. 1960 Nov 3;117:1469-71. Spanish. PubMed
PMID: 13725767.


4: PATEL JL, LEMBERGER AP. The kinetics of the hydrolysis of homatropine
methylbromide and atropine methylbromide. J Am Pharm Assoc Am Pharm Assoc. 1959
Feb;48(2):106-9. PubMed PMID: 13620573.


5: BANDELIN FJ. The colorimetric determination of homatropine methylbromide. J Am
Pharm Assoc Am Pharm Assoc. 1948 Jan;37(1):10-2. PubMed PMID: 18899761.


6: Canaes LS, Leite OD, Fatibello-Filho O. Flow-injection turbidimetric
determination of homatropine methylbromide in pharmaceutical formulations using
silicotungstic acid as precipitant reagent. Talanta. 2006 Mar 15;69(1):239-42.
doi: 10.1016/j.talanta.2005.09.035. Epub 2005 Oct 28. PubMed PMID: 18970560.


7: Hanna S, Rosen M, Rasero L, Lachman L. Analysis of homatropine methylbromide
dosage forms. J Pharm Sci. 1977 Jan;66(1):123-4. PubMed PMID: 576237.


8: Knochen M, Bardanca M, Piaggio P. Application of second-derivate UV
spectrophotometry to the determination of homatropine methylbromide in
single-component dosage form. Boll Chim Farm. 1987 Jul;126(7):294-7. PubMed PMID:
3452330.


9: WALTON CJ, CAYER D, SOHMER MF. Prolonged treatment of peptic ulcer with
homatropine methylbromide: a study of 58 patients under continuous therapy for
periods up to one year. N C Med J. 1959 May;20(5):181-4. PubMed PMID: 13657444.


10: CANTELMO AL. Adjunctive anticholinergic treatment with homatropine
methylbromide; a preliminary report. J Med Soc N J. 1955 Sep;52(9):471-3. PubMed
PMID: 13252392.


11: CAHEN RL, TVEDE K. Homatropine methylbromide; a pharmacological reevaluation.
J Pharmacol Exp Ther. 1952 Jun;105(2):166-77. PubMed PMID: 14928219.


12: Ahuja S, Spiegel D, Brofazi FR. Stabilization of homatropine
methylbromide-iodobismuthate complex in solution for quantitative analysis of
homatropine methylbromide. J Pharm Sci. 1970 Mar;59(3):417-8. PubMed PMID:
5416194.


13: Grabowski BF, Softly BJ, Chang BL, Haney WG Jr. GLC analysis of homatropine
methylbromide in tablets and elixirs. J Pharm Sci. 1973 May;62(5):806-9. PubMed
PMID: 4705690.


14: Cantwell FF, Domjan M, Hiskey CF. Specific analysis for homatropine
methylbromide in syrups. J Pharm Sci. 1974 Apr;63(4):599-603. PubMed PMID:
4828713.


15: Spiegel D, Ahuja S, Brofazi FR. Stability-indicating method for analysis of
homatropine methylbromide in pharmaceutical formulations. J Pharm Sci. 1972
Oct;61(10):1630-2. PubMed PMID: 5072413.


16: Limaiem F, Korbi S, Lahmar A, Bouraoui S, Aloui S, Jedidi S, Miloudi N,
Mzabi-Regaya S. A misleading hepatic tumour: epithelioid angiomyolipoma. Acta
Gastroenterol Belg. 2012 Dec;75(4):443-5. PubMed PMID: 23402089.


17: Fang L, Yu J, Jiang Z, Guo X. Preparation of a β-Cyclodextrin-Based
Open-Tubular Capillary Electrochromatography Column and Application for
Enantioseparations of Ten Basic Drugs. PLoS One. 2016 Jan 15;11(1):e0146292. doi:
10.1371/journal.pone.0146292. eCollection 2016. PubMed PMID: 26771454; PubMed
Central PMCID: PMC4714747.


18: Bassareo PP, Bassareo V, Manca D, Fanos V, Mercuro G. An old drug for use in
the prevention of sudden infant unexpected death due to vagal hypertonia. Eur J
Pediatr. 2011 Dec;170(12):1569-75. doi: 10.1007/s00431-011-1544-0. Epub 2011 Aug
4. PubMed PMID: 21814782.


19: Deolindo MV, Reis DG, Crestani CC, Tavares RF, Resstel LB, Corrêa FM. NMDA
receptors in the lateral hypothalamus have an inhibitory influence on the
tachycardiac response to acute restraint stress in rats. Eur J Neurosci. 2013
Aug;38(3):2374-81. doi: 10.1111/ejn.12246. Epub 2013 May 13. PubMed PMID:
23668726.


20: Zhu Z, Yang L, Zhao XM, Luo DQ, Zhang HT, Zhou CW. Myomatous hepatic
angiomyolipoma: imaging findings in 14 cases with radiological-pathological
correlation and review of the literature. Br J Radiol. 2014
Jun;87(1038):20130712. doi: 10.1259/bjr.20130712. Epub 2014 Mar 27. Review.
PubMed PMID: 24670055; PubMed Central PMCID: PMC4075552.