BAY-678

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522657

CAS#: Unknown

Description: BAY-678 is a potent, selective, cell-permeable HNE inhibitor. BAY-678 inhibits HNE reversibly with an in vitro IC50 = 20 nM and Ki = 15 nM. BAY-678 has more than 2,000-fold selectivity in a panel of 21 serine proteases, and there is no significant inhibition against 7 serine/threonine kinases and 64 pharmacologically relevant proteins.


Price and Availability

Size
Price

Size
Price

Size
Price

BAY-678 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 522657
Name: BAY-678
CAS#: Unknown
Chemical Formula: C20H15F3N4O2
Exact Mass: 400.1147
Molecular Weight: 400.3612
Elemental Analysis: C, 60.00; H, 3.78; F, 14.24; N, 13.99; O, 7.99


Synonym: BAY-678; BAY678; BAY 678.

IUPAC/Chemical Name: (R)-5-(5-acetyl-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-4-yl)picolinonitrile

InChi Key: PGIVGIFOWOVINL-GOSISDBHSA-N

InChi Code: InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1

SMILES Code: CC(C1=C(C)N(C2=CC=CC(C(F)(F)F)=C2)C(N[C@@H]1C3=CN=C(C#N)C=C3)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Human neutrophil elastase (HNE) is a serine protease with broad substrate specificity. It is linked to the pathologic processes of a variety of inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome, and cystic fibrosis. This highly active protease is able to break down mechanically important structures of the body’s own cellular matrix (e.g., proteins such as elastin and collagen), as well as proteins foreign to the body (e.g., outer cell wall proteins of Gram-negative bacteria). Accordingly, HNE is a potential target for the treatment of diseases and various HNE inhibitors have been described.

BAY-678 is cell-permeable, effluxratio = 2.7, and has a favorable pharmacokinetic profile. The cell based activity of BAY-678 on HNE is not relevant and has not been measured. Efficacy was demonstrated in acute in vivo models, for example, protease-induced acute lung injury (ALI) in mice, where exogenous HNE in the mouse lung was inhibited with Ki = 15 nM after oral administration.

(Copied from http://www.thesgc.org/chemical-probes/BAY-678)


References

1: von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M,
Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S,
Schamberger J. Potent and Selective Human Neutrophil Elastase Inhibitors with
Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine
BAY-8040 in a Pulmonary Arterial Hypertension Rat Model. ChemMedChem. 2016
Jan;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3. PubMed PMID:
26333652.

2: von Nussbaum F, Li VM, Allerheiligen S, Anlauf S, Bärfacker L, Bechem M,
Delbeck M, Fitzgerald MF, Gerisch M, Gielen-Haertwig H, Haning H, Karthaus D,
Lang D, Lustig K, Meibom D, Mittendorf J, Rosentreter U, Schäfer M, Schäfer S,
Schamberger J, Telan LA, Tersteegen A. Freezing the Bioactive Conformation to
Boost Potency: The Identification of BAY 85-8501, a Selective and Potent
Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015
Jul;10(7):1163-73. doi: 10.1002/cmdc.201500131. Epub 2015 Jun 17. PubMed PMID:
26083237; PubMed Central PMCID: PMC4515084.