Halofantrine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317986

CAS#: 36167-63-2

Description: Halofantrine hydrochloride is a blocker of delayed rectifier potassium current via the inhibition of hERG channel. It is an inhibitor of the hERG channel.


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Halofantrine hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317986
Name: Halofantrine hydrochloride
CAS#: 36167-63-2
Chemical Formula: C26H31Cl3F3NO
Exact Mass:
Molecular Weight: 536.88
Elemental Analysis: C, 58.16; H, 5.82; Cl, 19.81; F, 10.62; N, 2.61; O, 2.98


Synonym: Halofantrine hydrochloride; Halfan; Halofantrine HCl; Halofantrino [Spanish]; WR 171669; WR-171,669; WR-171699; halofantrine;

IUPAC/Chemical Name: 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride

InChi Key: WANGFTDWOFGECH-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H

SMILES Code: CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Taillardat-Bertschinger A, Perry CS, Galland A, Prankerd RJ, Charman WN.
Partitioning of halofantrine hydrochloride between water, micellar solutions, and
soybean oil: Effects on its apparent ionization constant. J Pharm Sci. 2003
Nov;92(11):2217-28. PubMed PMID: 14603507.

2: Adjene JO, Agoreyo FO. Effects of halofantrine hydrochloride (halfan) on the
histology of the ovary of mature female Wistar rats. Afr J Reprod Health. 2003
Apr;7(1):113-20. PubMed PMID: 12816318.

3: Khoo SM, Prankerd RJ, Edwards GA, Porter CJ, Charman WN. A physicochemical
basis for the extensive intestinal lymphatic transport of a poorly lipid soluble
antimalarial, halofantrine hydrochloride, after postprandial administration to
dogs. J Pharm Sci. 2002 Mar;91(3):647-59. PubMed PMID: 11920750.

4: Karle JM. X-ray crystal structure of the antimalarial agent (-)-halofantrine
hydrochloride supports stereospecificity for cardiotoxicity. Antimicrob Agents
Chemother. 1997 Apr;41(4):791-4. PubMed PMID: 9087491; PubMed Central PMCID:
PMC163796.

5: Del Nero L, Lamizana L, Nebie I, Sare S, Bougouma L, Pietra V. In vivo
sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina
Faso. Am J Trop Med Hyg. 1994 Jan;50(1):102-6. PubMed PMID: 8304564.

6: Gillespie SH, Msaki EP, Ramsay A, Ngowi FI, Fox R. A new micronized
formulation of halofantrine hydrochloride in the treatment of acute Plasmodium
falciparum malaria. Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):467-9. PubMed
PMID: 8249083.

7: Khan MA, Rehman GN, Qazi SA. Halofantrine hydrochloride--efficacy and safety
in children with acute malaria. J Pak Med Assoc. 1991 Jan;41(1):8-10. PubMed
PMID: 1900550.

8: Mashako MN, Kingway MP, Kayembe N. [Halofantrine hydrochloride in the
treatment of Plasmodium falciparum malaria in a region of resistance. Analysis of
54 pediatric cases]. Ann Soc Belg Med Trop. 1990 Mar;70(1):25-32. French. PubMed
PMID: 2196007.

9: Karle JM, Karle IL. Structure of the antimalarial halofantrine hydrochloride.
Acta Crystallogr C. 1989 Aug 15;45 ( Pt 8):1248-50. PubMed PMID: 2604946.

10: Wirima J, Khoromana C, Molyneux ME, Gilles HM. Clinical trials with
halofantrine hydrochloride in Malawi. Lancet. 1988 Jul 30;2(8605):250-2. PubMed
PMID: 2899238.