Halazepam
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317985

CAS#: 23092-17-3

Description: Halazepam is a benzodiazepine derivative. Halazepam was used for the treatment of anxiety. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.


Price and Availability

Size
Price

200mg
USD 610
Size
Price

Size
Price

Halazepam, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317985
Name: Halazepam
CAS#: 23092-17-3
Chemical Formula: C17H12ClF3N2O
Exact Mass: 352.05903
Molecular Weight: 352.74
Elemental Analysis: C, 57.88; H, 3.43; Cl, 10.05; F, 16.16; N, 7.94; O, 4.54


Synonym: Halazepam; Paxipam; Pacinone; Halazepamum; Schering 12041; Sch 12041;

IUPAC/Chemical Name: 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one

InChi Key: WYCLKVQLVUQKNZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12ClF3N2O/c18-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)22-9-15(24)23(14)10-17(19,20)21/h1-8H,9-10H2

SMILES Code: C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3)CC(F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lu XL, Guengerich FP, Yang SK. Stereoselective metabolism of prazepam and
halazepam by human liver microsomes. Drug Metab Dispos. 1991
May-Jun;19(3):637-42. PubMed PMID: 1680631.

2: Wala EP, Sloan JW, Martin WR, Pruitt T. Pharmacokinetics and metabolism of
halazepam in naive and dependent dogs. Pharmacol Biochem Behav. 1991
Mar;38(3):561-7. PubMed PMID: 1676848.

3: Lozano, Crespo, O'Neil, Pelegrín, De Pablo, Bayas, Díaz, Viñas, Moreno. [Open
clinical study of the efficacy and safety of Halazepam in anxiety disorders].
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1990 Jul-Aug;18(4):205-11. Spanish.
PubMed PMID: 1981637.

4: Lu XL, Yang SK. Metabolism of halazepam by rat liver microsomes:
stereoselective formation and N-dealkylation of 3-hydroxyhalazepam. Chirality.
1990;2(1):1-9. PubMed PMID: 2400636.

5: Gupta SK, Ellinwood EH Jr. Liquid chromatographic determination of halazepam
in commercial tablets. J Chromatogr. 1988 Jul 8;445(1):310-3. PubMed PMID:
2905708.

6: Mendels J, Wasserman TW, Michals TJ, Fine EW. Halazepam in the management of
acute alcohol withdrawal syndrome. J Clin Psychiatry. 1985 May;46(5):172-4.
PubMed PMID: 2859274.

7: Halazepam (Paxipam)--another benzodiazepine. Med Lett Drugs Ther. 1982 May
14;24(609):50. PubMed PMID: 6123073.

8: Fann WE, Pitts WM, Wheless JC. Pharmacology, efficacy, and adverse effects of
halazepam, a new benzodiazepine. Pharmacotherapy. 1982 Mar-Apr;2(2):72-9. Review.
PubMed PMID: 6152591.

9: McEvilly JP, Etemad B. A double-blind parallel-group comparison of single
bedtime doses of halazepam and placebo. J Int Med Res. 1980;8(5):368-73. PubMed
PMID: 6106612.

10: Zisook S, Rogers PJ, Faschingbauer TR, Devaul RA. Absence of hostility in
outpatients after administration of halazepam--a new benzodiazepine. J Clin
Psychiatry. 1978 Aug;39(8):683-5. PubMed PMID: 681309.

11: Kellner R, Bruzzese D, Winslow WW, Rada RT, Wall FJ. The effects of one-day
treatment of anxiety with high doses of halazepam. J Clin Pharmacol. 1978
Apr;18(4):203-9. PubMed PMID: 24645.

12: Rickels K, Case WG, Chung H, Downing RW, Vlahovich J. Diazepam and halazepam
in anxiety: some prognostic indicators. Int Pharmacopsychiatry.
1978;13(2):118-25. PubMed PMID: 27465.

13: Calvo Villas JM, Zapata Ramos F, Lluch Perales J, García Zerpa C.
[Neurileptic malignant syndrome. A case associated with halazepam and fluoxetine
treatment]. An Med Interna. 2000 Sep;17(9):511-2. Spanish. PubMed PMID: 11100548.

14: Sloan JW, Martin WR, Wala E, Dickey KM. Chronic administration of and
dependence on halazepam, diazepam, and nordiazepam in the dog. Drug Alcohol
Depend. 1991 Oct;28(3):249-64. PubMed PMID: 1684320.

15: Gupta SK, Ellinwood EH. Liquid chromatographic assay and pharmacokinetics of
halazepam and its metabolite in humans. J Pharm Sci. 1990 Sep;79(9):822-5. PubMed
PMID: 1980307.

16: Chung M, Hilbert JM, Gural RP, Radwanski E, Symchowicz S, Zampaglione N.
Multiple-dose halazepam kinetics. Clin Pharmacol Ther. 1984 Jun;35(6):838-42.
PubMed PMID: 6145534.

17: Jaffe JH, Ciraulo DA, Nies A, Dixon RB, Monroe LL. Abuse potential of
halazepam and of diazepam in patients recently treated for acute alcohol
withdrawal. Clin Pharmacol Ther. 1983 Nov;34(5):623-30. PubMed PMID: 6627822.

18: Greenblatt DJ, Locniskar A, Shader RI. Halazepam as a precursor of
desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography.
Psychopharmacology (Berl). 1983;80(2):178-80. PubMed PMID: 6410448.

19: Greenblatt DJ, Locniskar A, Shader RI. Halazepam, another precursor of
desmethyldiazepam. Lancet. 1982 Jun 12;1(8285):1358-9. PubMed PMID: 6123659.

20: New benzodiazepines: temazepam, halazepam, alprazolam, and triazolam. J Clin
Psychopharmacol. 1982 Jun;2(3):159-60. PubMed PMID: 6124558.