JJKK048
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522652

CAS#: 1515855-97-6

Description: JJKK048 is an ultrapotent and highly selective inhibitors of monoacylglycerol lipase. JJKK-048 potently (IC50 < 0.4 nM) inhibited human and rodent MAGL. JJKK-048 displayed low cross-reactivity with other endocannabinoid targets. Monoacylglycerol lipase (MAGL) terminates the signaling function of the endocannabinoid, 2-arachidonoylglycerol (2-AG). During 2-AG hydrolysis, MAGL liberates arachidonic acid, feeding the principal substrate for the neuroinflammatory prostaglandins. In cancer cells, MAGL redirects lipid stores toward protumorigenic signaling lipids. Thus MAGL inhibitors may have great therapeutic potential.


Price and Availability

Size
Price

5mg
USD 230
Size
Price

25mg
USD 570
Size
Price

JJKK048, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522652
Name: JJKK048
CAS#: 1515855-97-6
Chemical Formula: C23H22N4O5
Exact Mass: 434.159
Molecular Weight: 434.452
Elemental Analysis: C, 63.59; H, 5.10; N, 12.90; O, 18.41


Synonym: JJKK048; JJKK-048; JJKK 048.

IUPAC/Chemical Name: (4-(bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone

InChi Key: CLSNATLUIXZPMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12,15,22H,5-8,13-14H2

SMILES Code: O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)C4=CC=C(OCO5)C5=C4)CC1)N6N=CN=C6


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J,
Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T,
Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT. Piperazine and
piperidine triazole ureas as ultrapotent and highly selective inhibitors of
monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90. doi:
10.1016/j.chembiol.2013.01.012. PubMed PMID: 23521796.