Ipratropium bromide hydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318066

CAS#: 66985-17-9 (bromide hydrate)

Description: Ipratropium bromide is a medication that opens up the medium and large airways in the lungs. It is used to treat the symptoms of chronic obstructive pulmonary disease and asthma. It is administered by inhaler or nebulizer. Onset of action is typically within 15 to 30 minutes and lasts for three to five hours.

Chemical Structure

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Ipratropium bromide hydrate
CAS# 66985-17-9 (bromide hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 318066
Name: Ipratropium bromide hydrate
CAS#: 66985-17-9 (bromide hydrate)
Chemical Formula: C20H32BrNO4
Exact Mass: 0.00
Molecular Weight: 430.383
Elemental Analysis: C, 55.82; H, 7.49; Br, 18.57; N, 3.25; O, 14.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 60205-81-4 (cation)   22254-24-6 (bromide)   66985-17-9 (bromide hydrate)   922491-06-3 (bromide hydrate)    

Synonym: Ipratropium bromide, Atrovent, Apovent, Ipraxa, Rinatec

IUPAC/Chemical Name: [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;bromide hydrate

InChi Key: KEWHKYJURDBRMN-XFQAGIBXSA-M

InChi Code: InChI=1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18?,19?,21?;;

SMILES Code: O=C(OC1C[C@]([N+]2(C)C(C)C)([H])CC[C@]2([H])C1)C(C3=CC=CC=C3)CO.[H]O[H].[Br-]

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cheyne L, Irvin-Sellers MJ, White J. Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015 Sep 22;9:CD009552. doi: 10.1002/14651858.CD009552.pub3. Review. PubMed PMID: 26391969.

2: Cheyne L, Irvin-Sellers MJ, White J. Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2013 Sep 16;9:CD009552. doi: 10.1002/14651858.CD009552.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;9:CD009552. PubMed PMID: 24043433.

3: AlBalawi ZH, Othman SS, Alfaleh K. Intranasal ipratropium bromide for the common cold. Cochrane Database Syst Rev. 2013 Jun 19;6:CD008231. doi: 10.1002/14651858.CD008231.pub3. Review. PubMed PMID: 23784858.

4: Panos RJ. Efficacy and safety of eco-friendly inhalers: focus on combination ipratropium bromide and albuterol in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2013;8:221-30. doi: 10.2147/COPD.S31246. Epub 2013 Apr 30. Review. PubMed PMID: 23658481; PubMed Central PMCID: PMC3643287.

5: Albalawi ZH, Othman SS, Alfaleh K. Intranasal ipratropium bromide for the common cold. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008231. doi: 10.1002/14651858.CD008231.pub2. Review. Update in: Cochrane Database Syst Rev. 2013;6:CD008231. PubMed PMID: 21735425.

6: Gordon J, Panos RJ. Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease. Expert Opin Drug Metab Toxicol. 2010 Mar;6(3):381-92. doi: 10.1517/17425251003649549. Review. PubMed PMID: 20163324.

7: Dotson K, Dallman M, Bowman CM, Titus MO. Ipratropium bromide for acute asthma exacerbations in the emergency setting: a literature review of the evidence. Pediatr Emerg Care. 2009 Oct;25(10):687-92; quiz 693-5. doi: 10.1097/PEC.0b013e3181b95084. Review. PubMed PMID: 19834421.

8: Appleton S, Jones T, Poole P, Pilotto L, Adams R, Lasserson TJ, Smith B, Muhammad J. Ipratropium bromide versus long-acting beta-2 agonists for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD006101. Review. PubMed PMID: 16856113.

9: Wellington K. Ipratropium bromide HFA. Treat Respir Med. 2005;4(3):215-20; discussion 221-2. Review. PubMed PMID: 15987237.

10: Kässner F, Hodder R, Bateman ED. A review of ipratropium bromide/fenoterol hydrobromide (Berodual) delivered via Respimat Soft Mist Inhaler in patients with asthma and chronic obstructive pulmonary disease. Drugs. 2004;64(15):1671-82. Review. PubMed PMID: 15257628.

11: Rowe BH, Travers AH, Holroyd BR, Kelly KD, Bota GW. Nebulized ipratropium bromide in acute pediatric asthma: does it reduce hospital admissions among children presenting to the emergency department? Ann Emerg Med. 1999 Jul;34(1):75-85. Review. PubMed PMID: 10381998.

12: Delacourt C, de Blic J, Lebourgeois M, Scheinmann P. [Value of ipratropium bromide in asthma crisis in children]. Arch Pediatr. 1994 Jan;1(1):87-92. Review. French. PubMed PMID: 8087227.

13: Gross NJ. Ipratropium bromide. N Engl J Med. 1988 Aug 25;319(8):486-94. Review. PubMed PMID: 2970009.

14: Milner AD. Ipratropium bromide and airways obstruction in childhood. Postgrad Med J. 1987;63 Suppl 1:53-6. Review. PubMed PMID: 2962075; PubMed Central PMCID: PMC2428433.

15: Chervinsky P. Concomitant bronchodilator therapy and ipratropium bromide. A clinical review. Am J Med. 1986 Nov 14;81(5A):67-73. Review. PubMed PMID: 2947463.

16: Schlueter DP. Ipratropium bromide in asthma. A review of the literature. Am J Med. 1986 Nov 14;81(5A):55-60. Review. PubMed PMID: 2947461.

17: Morris HG. Review of ipratropium bromide in induced bronchospasm in patients with asthma. Am J Med. 1986 Nov 14;81(5A):36-44. Review. PubMed PMID: 2947459.

18: Cugell DW. Clinical pharmacology and toxicology of ipratropium bromide. Am J Med. 1986 Nov 14;81(5A):18-22. Review. PubMed PMID: 2947457.

19: Massey KL, Gotz VP. Ipratropium bromide. Drug Intell Clin Pharm. 1985 Jan;19(1):5-12. Review. PubMed PMID: 3155676.

20: Pakes GE, Brogden RN, Heel RC, Speight TM, Avery GS. Ipratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis. Drugs. 1980 Oct;20(4):237-66. Review. PubMed PMID: 6448137.