Rabeximod

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319916

CAS#: 872178-65-9

Description: Rabeximod, also known as ROB-803; is an immunomodulator agent. Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders. Rabeximod suppresses arthritis by preventing activation of inflammatory cells, most likely macrophages, in a time dependent fashion, downstream of TLR2 and TLR4 stimulation. Anti-inflammatory treatment of traumatic brain injury with Rabeximod reduces cerebral antigen presentation in mice.


Price and Availability

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Rabeximod is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international). Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319916
Name: Rabeximod
CAS#: 872178-65-9
Chemical Formula: C22H24ClN5O
Exact Mass: 409.1669
Molecular Weight: 409.918
Elemental Analysis: C, 64.46; H, 5.90; Cl, 8.65; N, 17.09; O, 3.90


Synonym: ROB-803; ROB-803; ROB-803; Rabeximod.

IUPAC/Chemical Name: 2-(9-chloro-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide

InChi Key: PDNNUMNEXITLCZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24ClN5O/c1-13-9-17-18(10-14(13)2)26-22-21(25-17)16-11-15(23)5-6-19(16)28(22)12-20(29)24-7-8-27(3)4/h5-6,9-11H,7-8,12H2,1-4H3,(H,24,29)

SMILES Code: O=C(NCCN(C)C)CN(C1=NC2=CC(C)=C(C)C=C2N=C13)C4=C3C=C(Cl)C=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Israelsson C, Kylberg A, Björklund U, Ebendal T. Anti-inflammatory treatment
of traumatic brain injury with Rabeximod reduces cerebral antigen presentation in
mice. J Neurosci Res. 2015 Oct;93(10):1519-25. doi: 10.1002/jnr.23607. Epub 2015
Jun 10. PubMed PMID: 26068706.

2: Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R. Rabeximod reduces
arthritis severity in mice by decreasing activation of inflammatory cells. Ann
Rheum Dis. 2010 Aug;69(8):1527-32. doi: 10.1136/ard.2009.121178. Epub 2010 Jun
11. PubMed PMID: 20542961.

3: Giusti P, Frascaroli G, Tammik C, Gredmark-Russ S, Söderberg-Nauclér C, Varani
S. The novel anti-rheumatic compound Rabeximod impairs differentiation and
function of human pro-inflammatory dendritic cells and macrophages.
Immunobiology. 2011 Jan-Feb;216(1-2):243-50. doi: 10.1016/j.imbio.2010.04.004.
Epub 2010 Apr 28. PubMed PMID: 20494473.

4: Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R. The novel small molecule
drug Rabeximod is effective in reducing disease severity of mouse models of
autoimmune disorders. Ann Rheum Dis. 2009 Jan;68(1):130-5. doi:
10.1136/ard.2007.085241. Epub 2008 Mar 17. PubMed PMID: 18347009.