Gallamine Triethiodide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317964

CAS#: 65-29-2

Description: Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. It acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. It is a synthetic non-depolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output.


Price and Availability

Size
Price

50mg
USD 150
500mg
USD 250
5g
USD 450
50g
Ask price
Size
Price

100mg
USD 180
1g
USD 280
10g
USD 650
100g
Ask price
Size
Price

200mg
USD 210
2g
USD 350
20g
USD 850

Gallamine Triethiodide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317964
Name: Gallamine Triethiodide
CAS#: 65-29-2
Chemical Formula: C30H60I3N3O3
Exact Mass:
Molecular Weight: 891.53
Elemental Analysis: C, 40.42; H, 6.78; I, 42.70; N, 4.71; O, 5.38


Synonym: Gallamine Triethiodide; Flaxedil; Tricuran; Gallamoni jodidum; Gallaminii iodidum; Triethyl Iodide, Gallamine; Iodide, Gallamine; Triethyl Iodide, Gallamonium; Gallamine Triethochloride;

IUPAC/Chemical Name: 2-[2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium triiodide

InChi Key: REEUVFCVXKWOFE-UHFFFAOYSA-K

InChi Code: InChI=1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3

SMILES Code: CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC.[I-].[I-].[I-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ali AM, Ghandour MA, Abd-El-Fattah MM. Cathodic adsorptive stripping
voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil).
J Pharm Biomed Anal. 2001 Apr;25(1):31-7. PubMed PMID: 11274856.

2: Al-Jafari AA. The inhibitory effect of the neuromuscular blocking agent,
gallamine triethiodide, on camel retina acetylcholinesterase activity. Toxicol
Lett. 1997 Jan 15;90(1):45-51. PubMed PMID: 9020401.

3: Schauf CL, Smith KJ. Gallamine triethiodide-induced modifications of sodium
conductance in Myxicola giant axons. J Physiol. 1982 Feb;323:157-71. PubMed PMID:
6284914; PubMed Central PMCID: PMC1250350.

4: Ramzan MI, Triggs EJ, Shanks CA. Pharmacokinetic studies in man with gallamine
triethiodide. II. Single 4 and 6 mg/kg i.v. doses. Eur J Clin Pharmacol. 1980
Feb;17(2):145-52. PubMed PMID: 7371706.

5: Fisher MM. Anaphylactic reactions to gallamine triethiodide. Anaesth Intensive
Care. 1978 Feb;6(1):62-5. PubMed PMID: 665980.

6: Evans PJ, McKinnon I. An anaphylactoid reaction to gallamine triethiodide.
Anaesth Intensive Care. 1977 Aug;5(3):239-43. PubMed PMID: 19987.

7: Smalley N. Gallamine triethiodide. AANA J. 1975 Oct;43(5):487-91. PubMed PMID:
1043597.

8: Shembekar AG, Deshpande VR. Antiarrhythmic activity of ethosuximide and
gallamine triethiodide in experimentally induced arrhythmias. Indian J Physiol
Pharmacol. 1974 Oct-Dec;18(4):330-3. PubMed PMID: 4466791.

9: Kölliker K. The effects of pancuronium bromide and gallamine triethiodide
during barbiturate, N 2 O--halothane anaesthesia. Acta Anaesthesiol Scand.
1972;16(4):240-5. PubMed PMID: 4265584.

10: Sezaki T, Okamura H, Nakamura T, Sagara T, Matsuoka A. [Clinical study of
gallamine triethiodide in cardiotomy under simple extreme hypothermia]. Masui.
1969 Sep;18(9):863-70. Japanese. PubMed PMID: 5389154.

11: Farman JV, Kennedy BR. Circulatory effects of atropine in patients
anaesthetized with gallamine triethiodide and nitrous oxide. Br J Anaesth. 1969
Jan;41(1):38-46. PubMed PMID: 5774304.

12: Kennedy BR, Farman JV. Cardiovascular effects of gallamine triethiodide in
man. Br J Anaesth. 1968 Oct;40(10):773-80. PubMed PMID: 5698532.

13: Ascione PP, Zagar JB, Chrekian GP. Quantitative determination of gallamine
triethiodide. J Pharm Sci. 1968 Oct;57(10):1768-70. PubMed PMID: 4300952.

14: Halpern LM, Black RG. Gallamine triethiodide facilitation of local cortical
excitability compared with other neuromuscular blocking agents. J Pharmacol Exp
Ther. 1968 Jul;162(1):166-73. PubMed PMID: 5656595.

15: Halpern LM, Black RG. Evidence for a central action of gallamine triethiodide
(Flaxedil). Proc West Pharmacol Soc. 1967;10:37-8. PubMed PMID: 6055501.

16: THOMAS ET. The effect of gallamine triethiodide on blood pressure.
Anaesthesia. 1963 Jul;18:316-23. PubMed PMID: 13981064.

17: GREENFIELD W, IMIG CJ, EVONUK E. Effect of gallamine triethiodide and
pentobarbital on certain cardiovascular and respiratory events. Am J Physiol.
1961 Apr;200:801-3. PubMed PMID: 13708321.

18: MAPLESON WW, MUSHIN WM. Relaxant action in man; an experimental study. II.
Results with intravenous gallamine triethiodide. Anaesthesia. 1955
Oct;10(4):379-90. PubMed PMID: 13259126.

19: PITTINGER CB. Observations of the placental transmission of gallamine
triethiodide (flaxedil), succinylcholine chloride (anectine) and decamethonium
bromide (syncurine) in dogs. Curr Res Anesth Analg. 1955 Mar-Apr;34(2):107-11.
PubMed PMID: 14365201.

20: FOLDES FF, MACHAJ TS, CARBERRY PC. The use of gallamine triethiodide
(flaxedil) with pentothal sodium-nitrous oxide-oxygen anesthesia in abdominal
surgery. Curr Res Anesth Analg. 1954 Mar-Apr;33(2):122-8. PubMed PMID: 13141704.